About: The Immunopathology of Sepsis: Pathogen Recognition, Systemic Inflammation, the Compensatory Anti‐Inflammatory Response, and Regulatory T Cells

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About: The Immunopathology of Sepsis: Pathogen Recognition, Systemic Inflammation, the Compensatory Anti‐Inflammatory Response, and Regulatory T Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Immunopathology of Sepsis: Pathogen Recognition, Systemic Inflammation, the Compensatory Anti‐Inflammatory Response, and Regulatory T Cells
Creator	Chan, D Garden, O Armitage-Chan, E Lewis, D Pinheiro, D
topic	covid:3cb3db1d96357bafc65e97ba5e4cb92c51dad4b9#this
Source	Medline; PMC
abstract	Sepsis, the systemic inflammatory response to infection, represents the major cause of death in critically ill veterinary patients. Whereas important advances in our understanding of the pathophysiology of this syndrome have been made, much remains to be elucidated. There is general agreement on the key interaction between pathogen‐associated molecular patterns and cells of the innate immune system, and the amplification of the host response generated by pro‐inflammatory cytokines. More recently, the concept of immunoparalysis in sepsis has also been advanced, together with an increasing recognition of the interplay between regulatory T cells and the innate immune response. However, the heterogeneous nature of this syndrome and the difficulty of modeling it in vitro or in vivo has both frustrated the advancement of new therapies and emphasized the continuing importance of patient‐based clinical research in this area of human and veterinary medicine.
has issue date	2012-03-17(xsd:dateTime)
bibo:doi	10.1111/j.1939-1676.2012.00905.x
bibo:pmid	22428780
has license	no-cc
sha1sum (hex)	3cb3db1d96357bafc65e97ba5e4cb92c51dad4b9
schema:url	https://doi.org/10.1111/j.1939-1676.2012.00905.x
resource representing a document's title	The Immunopathology of Sepsis: Pathogen Recognition, Systemic Inflammation, the Compensatory Anti‐Inflammatory Response, and Regulatory T Cells
has PubMed Central identifier	PMC7166777
has PubMed identifier	22428780
schema:publication	J Vet Intern Med
resource representing a document's body	covid:3cb3db1d96357bafc65e97ba5e4cb92c51dad4b9#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/3cb3db1d96357bafc65e97ba5e4cb92c51dad4b9
is schema:about of	named entity 'infection' named entity 'host response' named entity 'pathogen-associated molecular patterns' named entity 'Regulatory T Cells' named entity 'AREA' named entity 'SYNDROME' named entity 'REMAINS' named entity 'HUMAN' named entity 'IMPORTANT' named entity 'MODELING' named entity 'AMPLIFICATION' named entity 'CONCEPT' named entity 'ASSOCIATED' named entity 'SYSTEMIC' named entity 'INFLAMMATORY RESPONSE' named entity 'SEPSIS' named entity 'CLINICAL RESEARCH' named entity 'pathophysiology' named entity 'Sepsis' named entity 'innate immune response' named entity 'myocytes' named entity 'cell death' named entity 'TNF' named entity 'sepsis' named entity 'TLRs' named entity 'TGF-b' named entity 'TNFR2' named entity 'dermis' named entity 'effector cells' named entity 'inflammation' named entity 'TNF-a' named entity 'monocytes' named entity 'plasma membrane' named entity 'signaling pathway' named entity 'TLRs' named entity 'serum' named entity 'alternative pathway' named entity 'Toll-Like Receptors' named entity 'PCR' named entity 'C-type lectin' named entity 'United States' named entity 'IL-10' named entity 'myeloid' named entity 'naturally occurring' named entity 'antithrombin' named entity 'N-terminal' named entity 'Gram-negative' named entity 'IL-6' named entity 'transcription' named entity 'TLR 2' named entity 'upregulation' named entity 'CARD15' named entity 'PRRs' named entity 'ABIN' named entity 'TLR 9' named entity 'adaptive immune' named entity 'LDL' named entity 'Crohn's disease' named entity 'RIPK2' named entity 'IL-1b' named entity 'IL-1R' named entity 'Salmonella' named entity 'PCR' named entity 'Granulocyte colony-stimulating factor' named entity 'heat shock protein' named entity 'proapoptotic' named entity 'epidemiological studies' named entity 'caspase' named entity 'intravenous administration' named entity 'IL-1b' named entity 'intestinal tract' named entity 'TLRs' named entity 'Toll-like receptors' named entity 'canine' named entity 'LPS'

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