About: The Nucleocapsid Protein of Human Coronavirus NL63

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Nucleocapsid Protein of Human Coronavirus NL63 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Nucleocapsid Protein of Human Coronavirus NL63
Creator	Pyrc, Krzysztof Wojarski, Jacek Nowak, Paulina Golda, Anna Potempa, Jan Burmistrz, Michał Dobrucki, Jerzy Dubin, Grzegorz Florek, Dominik Kabala, Wojciech Kedracka-Krok, Sylwia Zarebski, Mirosław Zdzalik, Michal Zeglen, Sławomir Zuwała, Kaja
source	Medline; PMC
abstract	Human coronavirus (HCoV) NL63 was first described in 2004 and is associated with respiratory tract disease of varying severity. At the genetic and structural level, HCoV-NL63 is similar to other members of the Coronavirinae subfamily, especially human coronavirus 229E (HCoV-229E). Detailed analysis, however, reveals several unique features of the pathogen. The coronaviral nucleocapsid protein is abundantly present in infected cells. It is a multi-domain, multi-functional protein important for viral replication and a number of cellular processes. The aim of the present study was to characterize the HCoV-NL63 nucleocapsid protein. Biochemical analyses revealed that the protein shares characteristics with homologous proteins encoded in other coronaviral genomes, with the N-terminal domain responsible for nucleic acid binding and the C-terminal domain involved in protein oligomerization. Surprisingly, analysis of the subcellular localization of the N protein of HCoV-NL63 revealed that, differently than homologous proteins from other coronaviral species except for SARS-CoV, it is not present in the nucleus of infected or transfected cells. Furthermore, no significant alteration in cell cycle progression in cells expressing the protein was observed. This is in stark contrast with results obtained for other coronaviruses, except for the SARS-CoV.
has issue date	2015-02-20(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0117833
bibo:pmid	25700263
has license	cc0
sha1sum (hex)	3c8f08f49903aa46c23718a59a6bb221879aa1d2
schema:url	https://doi.org/10.1371/journal.pone.0117833
resource representing a document's title	The Nucleocapsid Protein of Human Coronavirus NL63
has PubMed Central identifier	PMC4336326
has PubMed identifier	25700263
schema:publication	PLoS One
resource representing a document's body	covid:3c8f08f49903aa46c23718a59a6bb221879aa1d2#body_text
is schema:about of	named entity 'homologous proteins' named entity 'protein' named entity 'N-terminal domain' named entity 'SARS-CoV' named entity 'SEVERITY' named entity 'CORONAVIRUSES' named entity 'HOMOLOGOUS' named entity 'LEVEL' named entity 'BIOCHEMICAL' named entity 'PROTEIN ' named entity 'GENETIC' named entity 'N PROTEIN' named entity 'FEATURES' named entity 'NL63' named entity 'SARS-COV' named entity 'SIGNIFICANT' named entity 'CORONAVIRINAE' named entity 'UNIQUE' named entity 'STRUCTURAL' named entity 'AIM' named entity 'HUMAN CORONAVIRUS' named entity 'HUMAN CORONAVIRUS NL63' named entity 'OBSERVED' named entity 'REVEALED' named entity 'SHARES' named entity 'NOT PRESENT' named entity 'DOMAIN' named entity 'NUCLEOCAPSID PROTEIN' named entity 'CELLULAR PROCESSES' named entity 'FUNCTIONAL PROTEIN' named entity 'OBTAINED' named entity 'MEMBERS' named entity 'HUMAN CORONAVIRUS 229E' named entity 'PRESENT' named entity 'ANALYSIS' named entity 'SUBCELLULAR LOCALIZATION' named entity 'INVOLVED' named entity 'DESCRIBED' named entity 'RESULTS' named entity 'HCOV-NL63' named entity 'NUMBER OF' named entity 'INFECTED' named entity 'CONTRAST' named entity 'N-TERMINAL ' named entity 'VARYING' named entity 'GENOMES' named entity 'REVEALS' named entity 'VIRAL REPLICATION' named entity 'STUDY' named entity 'CHARACTERISTICS' named entity 'NUCLEUS' named entity 'DETAILED' named entity 'IS A' named entity 'SIMILAR' named entity 'PROTEIN ' named entity 'IMPORTANT' named entity 'ASSOCIATED WITH' named entity 'CELL CYCLE PROGRESSION' named entity 'PROTEINS' named entity 'PATHOGEN' named entity '229E' named entity 'PROTEIN OLIGOMERIZATION' named entity 'SPECIES' named entity 'NUCLEIC ACID BINDING' named entity 'EXCEPT FOR' named entity 'MULTI' named entity 'ALTERATION'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software