About: Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c‐Myc. Alternatively they can negatively regulate ubiquitin‐dependent signalling cascades such as the NF‐κB activation pathway. We review the current literature that associates DUBs with cancer and discuss their suitability as drug targets of the future. © 2010 IUBMB IUBMB Life, 62(2): 140–157, 2010   Goto Sponge  NotDistinct  Permalink

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  • Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c‐Myc. Alternatively they can negatively regulate ubiquitin‐dependent signalling cascades such as the NF‐κB activation pathway. We review the current literature that associates DUBs with cancer and discuss their suitability as drug targets of the future. © 2010 IUBMB IUBMB Life, 62(2): 140–157, 2010
Subject
  • Proteins
  • Neurochemistry
  • Chemical nomenclature
  • Oncogenes
  • Members of the International Council for Science
  • Organizations established in 1955
  • Scientific supraorganizations
  • International scientific organizations
  • Chemistry organizations
  • Molecular biology organizations
  • Standards organizations in Canada
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