About: Distinguishing Characteristics between Pandemic 2009–2010 Influenza A (H1N1) and Other Viruses in Patients Hospitalized with Respiratory Illness

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About: Distinguishing Characteristics between Pandemic 2009–2010 Influenza A (H1N1) and Other Viruses in Patients Hospitalized with Respiratory Illness Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Distinguishing Characteristics between Pandemic 2009–2010 Influenza A (H1N1) and Other Viruses in Patients Hospitalized with Respiratory Illness
Creator	Healey, Terrance Chapin, Kimberle Mills, John Cunha, Cheston Echenique, Ignacio Leveen, Emily Rybak, Natasha Andrea, Sarah Chan, Philip Mermel, Leonard Machan, Jason Mcculloh, Russell
Source	Medline; PMC
abstract	BACKGROUND: Differences in clinical presentation and outcomes among patients infected with pandemic 2009 influenza A H1N1 (pH1N1) compared to other respiratory viruses have not been fully elucidated. METHODOLOGY/PRINCIPAL FINDINGS: A retrospective study was performed of all hospitalized patients at the peak of the pH1N1 season in whom a single respiratory virus was detected by a molecular assay targeting 18 viruses/subtypes (RVP, Luminex xTAG). Fifty-two percent (615/1192) of patients from October, 2009 to December, 2009 had a single respiratory virus (291 pH1N1; 207 rhinovirus; 45 RSV A/B; 37 parainfluenza; 27 adenovirus; 6 coronavirus; and 2 metapneumovirus). No seasonal influenza A or B was detected. Individuals with pH1N1, compared to other viruses, were more likely to present with fever (92% & 70%), cough (92% & 86%), sore throat (32% & 16%), nausea (31% & 8%), vomiting (39% & 30%), abdominal pain (14% & 7%), and a lower white blood count (8,500/L & 13,600/L, all p-values<0.05). In patients with cough and gastrointestinal complaints, the presence of subjective fever/chills independently raised the likelihood of pH1N1 (OR 10). Fifty-five percent (336/615) of our cohort received antibacterial agents, 63% (385/615) received oseltamivir, and 41% (252/615) received steroids. The mortality rate of our cohort was 1% (7/615) and was higher in individuals with pH1N1 compared to other viruses (2.1% & 0.3%, respectively; p = 0.04). CONCLUSIONS/SIGNIFICANCE: During the peak pandemic 2009–2010 influenza season in Rhode Island, nearly half of patients admitted with influenza-like symptoms had respiratory viruses other than influenza A. A high proportion of patients were treated with antibiotics and pH1N1 infection had higher mortality compared to other respiratory viruses.
has issue date	2011-09-16(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0024734
bibo:pmid	21949746
has license	cc-by
sha1sum (hex)	3c3f097f19bb3dbbf56eb0f099af81054b305752
schema:url	https://doi.org/10.1371/journal.pone.0024734
resource representing a document's title	Distinguishing Characteristics between Pandemic 2009–2010 Influenza A (H1N1) and Other Viruses in Patients Hospitalized with Respiratory Illness
has PubMed Central identifier	PMC3174965
has PubMed identifier	21949746
schema:publication	PLoS One
resource representing a document's body	covid:3c3f097f19bb3dbbf56eb0f099af81054b305752#body_text
is schema:about of	named entity '2009' named entity 'Viruses' named entity 'HOSPITALIZED' named entity 'VIRUSES' named entity 'INFLUENZA A' named entity 'PANDEMIC' named entity 'CLINICAL PRESENTATION' named entity 'RESPIRATORY VIRUSES' named entity 'FULLY' named entity 'OUTCOMES' named entity 'RESPIRATORY ILLNESS' named entity 'INFLUENZA A' named entity 'PATIENTS' named entity 'HAVE' named entity 'COMPARED' named entity 'BACKGROUND' named entity 'PATIENTS' named entity 'INFECTED' named entity 'H1N1' named entity 'influenza A' named entity 'Influenza A (H1N1)' named entity 'Respiratory' named entity 'pH1N1' named entity 'viruses' named entity 'H1N1' named entity 'Respiratory Illness' named entity 'H1N1' named entity 'pH1N1' named entity 'intubation' named entity 'respiratory infection' named entity 'Rhode Island Hospital' named entity 'viruses' named entity 'CDC' named entity 'covariate' named entity 'influenza A virus' named entity 'antiviral medications' named entity 'fever' named entity 'pregnancy' named entity 'fever' named entity 'antibiotic' named entity 'virus' named entity '0.01' named entity 'rhinovirus' named entity 'influenza' named entity 'morbidity' named entity 'nursing home' named entity 'gastrointestinal' named entity 'coronavirus' named entity 'pH1N1' named entity 'pediatric' named entity 'antivirals' named entity 'influenza viruses' named entity 'viruses' named entity 'antibacterial agents' named entity 'influenza' named entity 'gastrointestinal' named entity 'adenovirus' named entity 'bilevel positive airway pressure' named entity 'influenza' named entity 'pH1N1' named entity '2.25' named entity 'ILI' named entity 'influenza' named entity 'metapneumovirus' named entity 'influenza infection' named entity 'PCR' named entity 'viruses' named entity 'Rhode Island Hospital' named entity 'clinical laboratories' named entity 'radiographic'

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