About: Current Trends in Diagnostics of Viral Infections of Unknown Etiology

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Current Trends in Diagnostics of Viral Infections of Unknown Etiology
Creator	Shipulin, German Khafizov, Kamil Abramov, Ivan Dedkov, Vladimir Kiselev, Daniel Matsvay, Alina
Source	Medline; PMC
abstract	Viruses are evolving at an alarming rate, spreading and inconspicuously adapting to cutting-edge therapies. Therefore, the search for rapid, informative and reliable diagnostic methods is becoming urgent as ever. Conventional clinical tests (PCR, serology, etc.) are being continually optimized, yet provide very limited data. Could high throughput sequencing (HTS) become the future gold standard in molecular diagnostics of viral infections? Compared to conventional clinical tests, HTS is universal and more precise at profiling pathogens. Nevertheless, it has not yet been widely accepted as a diagnostic tool, owing primarily to its high cost and the complexity of sample preparation and data analysis. Those obstacles must be tackled to integrate HTS into daily clinical practice. For this, three objectives are to be achieved: (1) designing and assessing universal protocols for library preparation, (2) assembling purpose-specific pipelines, and (3) building computational infrastructure to suit the needs and financial abilities of modern healthcare centers. Data harvested with HTS could not only augment diagnostics and help to choose the correct therapy, but also facilitate research in epidemiology, genetics and virology. This information, in turn, could significantly aid clinicians in battling viral infections.
has issue date	2020-02-14(xsd:dateTime)
bibo:doi	10.3390/v12020211
bibo:pmid	32074965
has license	cc-by
sha1sum (hex)	3bf6368f164189524748aa07f1a42fe808841b64
schema:url	https://doi.org/10.3390/v12020211
resource representing a document's title	Current Trends in Diagnostics of Viral Infections of Unknown Etiology
has PubMed Central identifier	PMC7077230
has PubMed identifier	32074965
schema:publication	Viruses
resource representing a document's body	covid:3bf6368f164189524748aa07f1a42fe808841b64#body_text
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