About: Employing Live Microbes for Vaccine Delivery

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Employing Live Microbes for Vaccine Delivery
Creator	Weiss, Siegfried Hamdorf, Matthias Komor, Uliana Leschner, Sara Loessner, Holger Schwantes, Astrid
Source	PMC
abstract	The employment of live attenuated vaccines has a long-standing record in human and veterinary medicine. Most of the vaccines in current use were empirically developed during the last century. Today, due to the great advances in fields such as immunology and bioengineering, the rational development of live attenuated vaccines becomes increasingly feasible. Moreover, live vaccines can be used as carrier systems for heterologous antigens or therapeutic factors. In each case, the development of a recombinant live attenuated vaccine is a complex task where properties such as targeting specificity, antigen synthesis, antigen release, and safety aspects have to be integrated. A range of such recombinant vaccine candidates have successfully been tested in the clinics, but very few have been approved so far. In many cases, further optimization of such vaccines is necessary with regard to their efficacy and safety profiles. In the present chapter, we focus on current strategies which are employed for the development of new and the optimization of first generation recombinant live vaccines based on bacteria and viruses.
has issue date	2012-02-18(xsd:dateTime)
bibo:doi	10.1007/978-3-7091-0709-6_5
has license	no-cc
sha1sum (hex)	3b97daece91268763e6995ace7c98d0ccc6a9a6b
schema:url	https://doi.org/10.1007/978-3-7091-0709-6_5
resource representing a document's title	Employing Live Microbes for Vaccine Delivery
has PubMed Central identifier	PMC7123214
schema:publication	Development of Novel Vaccines
resource representing a document's body	covid:3b97daece91268763e6995ace7c98d0ccc6a9a6b#body_text
is schema:about of	named entity 'development' named entity 'safety' named entity 'strategies' named entity 'IMMUNOLOGY' named entity 'RELEASE' named entity 'EFFICACY' named entity 'CENTURY' named entity 'RECOMBINANT' named entity 'LIVE ATTENUATED VACCINE' named entity 'CURRENT' named entity 'BUT' named entity 'THERAPEUTIC' named entity 'FAR' named entity 'CHAPTER' named entity 'RECOMBINANT VACCINE' named entity 'PRESENT' named entity 'SYSTEMS' named entity 'CASE' named entity 'VIRUSES' named entity 'ANTIGENS' named entity 'RECORD' named entity 'INTEGRATED' named entity 'USE' named entity 'HAVE' named entity 'THEIR' named entity 'HUMAN' named entity 'BASED' named entity 'CARRIER' named entity 'LONG' named entity 'PROPERTIES' named entity 'ANTIGEN' named entity 'TODAY' named entity 'OPTIMIZATION' named entity 'GENERATION' named entity 'BACTERIA ' named entity 'STANDING' named entity 'REGARD' named entity 'NECESSARY' named entity 'NEW' named entity 'EMPLOYED' named entity 'VETERINARY MEDICINE' named entity 'SPECIFICITY' named entity 'TARGETING' named entity 'TESTED' named entity 'TASK' named entity 'APPROVED' named entity 'DEVELOPMENT' named entity 'IS A' named entity 'BIOENGINEERING' named entity 'VACCINE DELIVERY' named entity 'LIVE' named entity 'EMPLOYING' named entity 'MICROBES' named entity 'CLINICS' named entity 'USED' named entity 'HETEROLOGOUS' named entity 'FOCUS' named entity 'COMPLEX' named entity 'EMPLOYMENT' named entity 'ATTENUATED VACCINES' named entity 'RANGE' named entity 'VACCINES' named entity 'CASES' named entity 'LIVE' named entity 'MOST OF' named entity 'SAFETY' named entity 'SYNTHESIS' named entity 'WHERE' named entity 'FEASIBLE' named entity 'GREAT' named entity 'DUE TO' named entity 'STRATEGIES' named entity 'developed' named entity 'vaccines' named entity 'recombinant vaccine' named entity 'optimization' named entity 'therapeutic' named entity 'advances'

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