About: Leptomeningitis and polycaryocyte formation in the CNS of rats inoculated subcutaneously with Herpes simplex virus

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About: Leptomeningitis and polycaryocyte formation in the CNS of rats inoculated subcutaneously with Herpes simplex virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Leptomeningitis and polycaryocyte formation in the CNS of rats inoculated subcutaneously with Herpes simplex virus
Creator	And, ~ Galil, K Hatch', L Percy,', D
Source	Elsevier; Medline; PMC
abstract	Abstract Wistar rats were inoculated subcutaneously with either type 1 (HSV1) or type 2 (HSV2) Herpes simplex virus at 5 days of age. Animals were killed in extremis or at the end of the 14-day observation period postinoculation. Acute destructive meningoencephalitis with hemorrhage and leukocytic infiltration was observed in both groups. Polycaryocytes comprised of cells of the internal granular layer of the cerebellum were observed in some animals inoculated with HSV1. These multinucleated cells appeared to be formed by fusion of virus-infected cells, and intranuclear inclusion bodies were observed. Lesions in the leptomeninges were particularly striking in animals inoculated with HSV2. Viral replication in resident cells of the leptomeninges was demonstrated by electron microscopy.
has issue date	1983-06-30(xsd:dateTime)
bibo:doi	10.1016/0014-4800(83)90079-5
bibo:pmid	6852211
has license	els-covid
sha1sum (hex)	3b415881cfa780561a787e742b3dd348f9f3cc91
schema:url	https://doi.org/10.1016/0014-4800%2883%2990079-5
resource representing a document's title	Leptomeningitis and polycaryocyte formation in the CNS of rats inoculated subcutaneously with Herpes simplex virus
has PubMed Central identifier	PMC7130222
has PubMed identifier	6852211
schema:publication	Experimental and Molecular Pathology
resource representing a document's body	covid:3b415881cfa780561a787e742b3dd348f9f3cc91#body_text
is schema:about of	named entity 'FORMATION' named entity 'killed' named entity 'inoculated' named entity 'Viral replication' named entity 'multinucleated cells' named entity 'striking' named entity 'STRIKING' named entity 'DESTRUCTIVE' named entity 'OBSERVED' named entity 'HSV' named entity 'ELECTRON MICROSCOPY' named entity 'FORMED' named entity 'INTRANUCLEAR INCLUSION BODIES' named entity 'EITHER' covid:arg/3b415881cfa780561a787e742b3dd348f9f3cc91 named entity 'HERPES SIMPLEX VIRUS' named entity 'RESIDENT' named entity 'FUSION' named entity 'WISTAR RATS' named entity 'GROUPS' named entity 'LEPTOMENINGES' named entity 'AT THE END' named entity 'KILLED' named entity 'TYPE 2' named entity 'INTERNAL GRANULAR LAYER OF THE CEREBELLUM' named entity 'DAY' named entity 'ACUTE' named entity 'AGE' named entity 'HEMORRHAGE' named entity 'OBSERVATION' named entity 'RATS' named entity 'LEPTOMENINGITIS' named entity 'CNS' named entity 'DAYS' named entity 'LESIONS' named entity 'THESE' named entity 'LEUKOCYTIC' named entity 'CELLS' named entity 'TYPE 1' named entity 'HERPES SIMPLEX VIRUS' named entity 'INFILTRATION' named entity 'PERIOD' named entity 'VIRAL REPLICATION' named entity 'MENINGOENCEPHALITIS' named entity 'MULTINUCLEATED' named entity 'ANIMALS' named entity 'meningoencephalitis' named entity 'inclusion bodies' named entity 'extremis' named entity 'electron microscopy' named entity 'groups' named entity 'animals' named entity 'destructive' named entity 'granular layer' named entity 'type 1' named entity 'multinucleated cells' named entity 'subcutaneously' named entity 'meningoencephalitis' named entity 'leptomeninges' named entity 'Leptomeningitis' named entity 'Animals' named entity 'leptomeningitis' named entity 'neonatal herpes' named entity 'syncytial' named entity 'tissue culture' named entity 'inoculation' named entity 'microgliosis' named entity 'skin lesions' named entity 'inoculation' named entity 'measles virus' named entity 'inflammatory cells' named entity 'encephalitis' named entity 'HEW' named entity 'endothelial cells' named entity 'mesencephalon' named entity 'hemorrhagic' named entity 'multinucleated giant cells' named entity 'rat'

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