About: SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers

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About: SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers
Creator	Mino-Kenudson, Mari Roberts, J David, • Dygulska, Beata Heyman, Taryn Salafia, Carolyn Bates, Sara Desai, Niyati Deshpande, • Drucilla, • Hecht, Jonathon Quade, • Shen, Dejun Ting, T
Source	Medline; PMC
abstract	Congenital infection of SARS-CoV-2 appears to be exceptionally rare despite many cases of COVID-19 during pregnancy. Robust proof of placental infection requires demonstration of viral localization within placental tissue. Only two of the few cases of possible vertical transmission have demonstrated placental infection. None have shown placental expression of the ACE2 or TMPRSS2 protein, both required for viral infection. We examined 19 COVID-19 exposed placentas for histopathologic findings, and for expression of ACE2, and TMPRSS2 by immunohistochemistry. Direct placental SARS-CoV-2 expression was studied by two methods—nucleocapsid protein expression by immunohistochemistry, and RNA expression by in situ hybridization. ACE2 membranous expression in the syncytiotrophoblast (ST) of the chorionic villi is predominantly in a polarized pattern with expression highest on the stromal side of the ST. In addition, cytotrophoblast and extravillous trophoblast express ACE2. No ACE2 expression was detected in villous stroma, Hofbauer cells, or endothelial cells. TMPRSS2 expression was only present weakly in the villous endothelium and rarely in the ST. In 2 of 19 cases, SARS-CoV-2 RNA was present in the placenta focally in the ST and cytotrophoblast. There was no characteristic histopathology present in our cases including the two placental infections. We found that the placenta is capable of being infected but that this event is rare. We propose one explanation could be the polarized expression of ACE2 away from the maternal blood and pronounced paucity of TMPRSS2 expression in trophoblast.
has issue date	2020-08-02(xsd:dateTime)
bibo:doi	10.1038/s41379-020-0639-4
bibo:pmid	32741970
has license	no-cc
sha1sum (hex)	3b3ea733255aa5db7241875b8e1d11edf80f97a1
schema:url	https://doi.org/10.1038/s41379-020-0639-4
resource representing a document's title	SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers
has PubMed Central identifier	PMC7395938
has PubMed identifier	32741970
schema:publication	Mod Pathol
resource representing a document's body	covid:3b3ea733255aa5db7241875b8e1d11edf80f97a1#body_text
is schema:about of	named entity 'viral' named entity 'histopathologic' named entity 'placental tissue' named entity 'TMPRSS2' named entity 'DURING PREGNANCY' named entity 'HOFBAUER CELLS' named entity 'STROMA' named entity 'EXPOSED' named entity 'infection' named entity 'rare' named entity 'expression' named entity 'expression' named entity 'expression' named entity 'COVID-19' named entity 'infections' named entity 'cases' named entity 'membranous' named entity 'protein' named entity 'immunohistochemistry' named entity 'COVID-19' named entity 'RNA' named entity 'exposed' named entity 'placental' named entity 'mothers' named entity 'placenta' named entity 'placenta' named entity 'placental' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'immunohistochemistry' named entity 'protein' named entity 'nucleocapsid protein' named entity 'chorionic villi' named entity 'COVID-19' named entity 'RNA' named entity 'ACE2' named entity 'TMPRSS2' named entity 'Congenital infection' named entity 'vertical transmission' named entity 'viral infection' named entity 'placental' named entity 'SARS-CoV-2' named entity 'placenta' named entity 'SARS-CoV-2' named entity 'Hepatitis C infection' named entity 'fibrin' named entity 'placenta' named entity 'virus' named entity 'trophoblast' named entity 'gross pathology' named entity 'histopathology' named entity 'endothelium' named entity 'placental' named entity 'infection' named entity 'SARS-CoV-2' named entity 'Leica Biosystems' named entity 'immunohistochemical' named entity 'umbilical cord' named entity 'trophoblast' named entity 'villous' named entity 'infection' named entity 'ACE2' named entity 'RNA' named entity 'intrauterine fetal demise' named entity 'viruses' named entity 'signal amplification' named entity 'staining' named entity 'fetal'

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