About: False-positive SARS-CoV-2 serology in three children with Kawasaki disease

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About: False-positive SARS-CoV-2 serology in three children with Kawasaki disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	False-positive SARS-CoV-2 serology in three children with Kawasaki disease
Creator	Fong, Carol Li, Xue Wong, Ian Ip, Patrick Chan, Chan, Kwok Clinical, Fong, Kw To, Kelvin Kwok, Hung Kwok, Yung Lam, Yu To, Kelvin Wong, Wong, Wilfred Yuen, Yuen, Yung Ka, Li Kwok, Ka Chua, Gilbert Ho, Marco Kwan, Lam, Yuen Patrick, Ip Ts Tung, Keith Tso, Winnie Wong, Christina Wong, Joshua Wong, Rosa Wong, Winnie Chi, Dennis Au, Yu Carol, H Chan, Celine Chui, Xue Godfrey, C Ip, Mike Kwan, Y Kwok, # Li, Keith Mike, # Sl Chui, Celine Tso, Ian Tung, Rosa Yuen, Patrick
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Kawasaki disease (KD) is an acute febrile and eruptive disease with systemic vasculitis predominantly affecting young East Asian children. Recent reports showed that children with KD-like disease from KD low prevalence regions had positive SARS-CoV-2 serology despite a negative SARS-CoV-2 polymerase chain reaction (PCR) in respiratory samples. OBJECTIVES: To describe three pediatric Kawasaki Disease patients with false positive SARS-CoV-2 serology. STUDY DESIGN: We retrospectively recruited children with KD diagnosed during the COVID-19 outbreak in Hong Kong. Clinical characteristics and laboratory test results including SARS-CoV-2 PCR results were retrieved. We performed a microparticle-based immunoassay for the detection of IgG against nucleoprotein (NP) and spike protein receptor binding domain (RBD), and a microneutralization assay for the detection of neutralizing antibodies. RESULTS: Three Chinese children with typical KD were identified. They had no epidemiological links with COVID-19 patients and tested negative for SARS-CoV-2 NPA PCR. They were treated with IVIG and aspirin, and were discharged without complications. Subsequently two of them were tested positive against anti-RBD and anti-NP antibodies and one was tested positive against anti- RBD antibodies. However, microneutralization assay showed that neutralizing antibodies were absent, suggesting a false-positive IgG result. CONCLUSION: Detection of neutralizing antibodies is recommended to confirm previous SARS-CoV-2 infection in IgG-positive but PCR-negative patients.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.1016/j.diagmicrobio.2020.115141
bibo:pmid	32795776
has license	no-cc
sha1sum (hex)	3a8f28431a417f5f8b65b89efb5dcf40a92515c5
schema:url	https://doi.org/10.1016/j.diagmicrobio.2020.115141
resource representing a document's title	False-positive SARS-CoV-2 serology in three children with Kawasaki disease
has PubMed Central identifier	PMC7366972
has PubMed identifier	32795776
schema:publication	Diagn Microbiol Infect Dis
resource representing a document's body	covid:3a8f28431a417f5f8b65b89efb5dcf40a92515c5#body_text
is schema:about of	named entity 'Journal' named entity 'assay' named entity 'patients' named entity 'neutralizing antibodies' named entity 'Detection' named entity 'serology' named entity 'POSITIVE' named entity 'antibodies' named entity 'Journal' named entity 'SARS-CoV-2' named entity 'neutralizing antibodies' named entity 'microneutralization' named entity 'IgG' named entity 'neutralizing antibodies' named entity 'RBD' named entity 'Kawasaki disease' named entity 'False-positive' named entity 'Epidemiologically' named entity 'Bergamo' named entity 'laboratory test' named entity 'exanthema' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'tested positive' named entity 'blood donors' named entity 'SARS-CoV-2' named entity 'immunoassay' named entity 'SARS-CoV-2' named entity 'COVID-19 outbreak' named entity 'neutralizing antibodies' named entity 'false positive' named entity 'aneurysms' named entity 'SARS-CoV-2' named entity 'IVIG' named entity 'serum' named entity 'RBD' named entity 'IgG' named entity 'tested positive'

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