About: Cytokine production pattern of T lymphocytes in neonatal arterial ischemic stroke during the first month of life

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Cytokine production pattern of T lymphocytes in neonatal arterial ischemic stroke during the first month of life—a case study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cytokine production pattern of T lymphocytes in neonatal arterial ischemic stroke during the first month of life—a case study
Creator	Bajnok, Anna Berta, László Orbán, Csaba Toldi, Gergely Tulassay, Tivadar
source	Medline; PMC
abstract	BACKGROUND: The perinatal period carries the highest risk for stroke in childhood; however, the pathophysiology is poorly understood and preventive, prognostic, and therapeutic strategies are not available. A new pathophysiological model describes the development of neonatal arterial ischemic stroke (NAIS) as the combined result of prenatal inflammation and hypoxic–ischemic insult. Neuroinflammation and a systemic inflammatory response are also important features of NAIS. Identifying key players of the inflammatory system is in the limelight of current research. CASE PRESENTATION: We present four NAIS cases, in whom detailed analysis of intracellular and plasma cytokine levels are available from the first month of life. All neonates were admitted with the initial diagnosis of hypoxic ischemic encephalopathy (HIE); however, early MRI examination revealed NAIS. Blood samples were collected between 3 and 6 h of life, at 24 h, 72 h, 1 week, and 1 month of life. Peripheral blood mononuclear cells were assessed with flow cytometry and plasma cytokine levels were measured. Pooled data from the cohort of four NAIS patients were compared to infants with HIE. At 6 and 72 h of age, the prevalence of IL10+ CD8+ lymphocytes remained lower in NAIS. At 6 h, CD8+ lymphocytes in NAIS produced more IL-17. At 72 h, CD8+ cells produced more IL-6 in severe HIE than in NAIS, but IL-6 production remained elevated in CD8 cells at 1 month in NAIS, while it decreased in HIE. At 1 week, the prevalence of TGF-β + lymphocytes prone to enter the CNS was elevated in NAIS. On the other hand, by 1 month of age, the prevalence of TGF-β + CD4+ lymphocytes decreased in NAIS compared to HIE. At 72 h, we found elevated plasma levels of IL-5, MCP-1, and IL-17 in NAIS. By 1 month, plasma levels of IL-4, IL-12, and IL-17 decreased in NAIS but remained elevated in HIE. CONCLUSIONS: Differences in the cytokine network are present between NAIS and HIE. CD8 lymphocytes appear to shift towards the pro-inflammatory direction in NAIS. The inflammatory response appears to be more pronounced at 72 h in NAIS but decreases faster, reaching lower plasma levels of inflammatory markers at 1 month.
has issue date	2018-06-22(xsd:dateTime)
bibo:doi	10.1186/s12974-018-1229-y
bibo:pmid	29933753
has license	cc-by
sha1sum (hex)	3a60c19b5cc401e24f815f8924010e77bed7579d
schema:url	https://doi.org/10.1186/s12974-018-1229-y
resource representing a document's title	Cytokine production pattern of T lymphocytes in neonatal arterial ischemic stroke during the first month of life—a case study
has PubMed Central identifier	PMC6015463
has PubMed identifier	29933753
schema:publication	J Neuroinflammation
resource representing a document's body	covid:3a60c19b5cc401e24f815f8924010e77bed7579d#body_text
is schema:about of	named entity 'T LYMPHOCYTES' named entity 'MONTH' named entity 'strategies' named entity 'early' named entity 'MRI' named entity 'Case' named entity 'CNS' named entity 'development' named entity 'life' named entity 'NAIS' named entity 'samples' named entity 'HIE' named entity 'PRESENT' named entity 'LYMPHOCYTES DECREASED' named entity 'PLAYERS' named entity 'FASTER' named entity 'PRENATAL' named entity 'HYPOXIC' named entity 'CHILDHOOD' named entity 'COMBINED' named entity 'KEY' named entity 'POOLED' named entity 'CASES' named entity 'SEVERE' named entity 'DEVELOPMENT' named entity 'MODEL' named entity 'RESULT' named entity 'MONTH' named entity 'HIGHEST' named entity 'CONCLUSIONS' named entity 'PREVENTIVE' named entity 'MEASURED' named entity 'PREVALENCE' named entity 'DECREASES' named entity 'INFLAMMATORY RESPONSE' named entity 'REACHING' named entity 'NEW' named entity 'CARRIES' named entity 'COHORT' named entity 'RISK' named entity 'DIRECTION' named entity 'BACKGROUND' named entity 'INFANTS' named entity '1 WEEK' named entity 'LEVELS' named entity 'IL-17' named entity 'PROGNOSTIC' named entity 'POORLY' named entity 'IL10' named entity 'IL-4' named entity 'BUT' named entity 'CD4' named entity 'LYMPHOCYTES' named entity 'DETAILED' named entity 'IDENTIFYING' named entity 'ELEVATED' named entity 'NAIS' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'IL-6 PRODUCTION' named entity 'BLOOD SAMPLES' named entity 'TO SHIFT' named entity 'ADMITTED' named entity 'IL-12' named entity 'CD8 CELLS' named entity 'COLLECTED' named entity 'CURRENT' named entity 'LIFE' named entity 'IL-6' named entity 'FEATURES' named entity 'INFLAMMATORY MARKERS' named entity 'COMPARED' named entity 'NOT AVAILABLE' named entity 'EARLY' named entity 'DATA' named entity 'STRATEGIES' named entity 'NEONATAL' named entity 'PERINATAL PERIOD'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software