About: Haemophilus is overrepresented in the nasopharynx of infants hospitalized with RSV infection and associated with increased viral load and enhanced mucosal CXCL8 responses

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About: Haemophilus is overrepresented in the nasopharynx of infants hospitalized with RSV infection and associated with increased viral load and enhanced mucosal CXCL8 responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Haemophilus is overrepresented in the nasopharynx of infants hospitalized with RSV infection and associated with increased viral load and enhanced mucosal CXCL8 responses
Creator	Ferwerda, Gerben Ahout, Inge Boekhorst, Jos Vissers, Marloes De Groot, Ronald De Jonge, Marien Ederveen, Thomas Huynen, Martijn Timmerman, Harro Van Hijum, Sacha
Source	Medline; PMC
abstract	BACKGROUND: While almost all infants are infected with respiratory syncytial virus (RSV) before the age of 2 years, only a small percentage develops severe disease. Previous studies suggest that the nasopharyngeal microbiome affects disease development. We therefore studied the effect of the nasopharyngeal microbiome on viral load and mucosal cytokine responses, two important factors influencing the pathophysiology of RSV disease. To determine the relation between (i) the microbiome of the upper respiratory tract, (ii) viral load, and (iii) host mucosal inflammation during an RSV infection, nasopharyngeal microbiota profiles of RSV infected infants (< 6 months) with different levels of disease severity and age-matched healthy controls were determined by 16S rRNA marker gene sequencing. The viral load was measured using qPCR. Nasopharyngeal CCL5, CXCL10, MMP9, IL6, and CXCL8 levels were determined with ELISA. RESULTS: Viral load in nasopharyngeal aspirates of patients associates significantly to total nasopharyngeal microbiota composition. Healthy infants (n = 21) and RSV patients (n = 54) display very distinct microbial patterns, primarily characterized by a loss in commensals like Veillonella and overrepresentation of opportunistic organisms like Haemophilus and Achromobacter in RSV-infected individuals. Furthermore, nasopharyngeal microbiota profiles are significantly different based on CXCL8 levels. CXCL8 is a chemokine that was previously found to be indicative for disease severity and for which we find Haemophilus abundance as the strongest predictor for CXCL8 levels. CONCLUSIONS: The nasopharyngeal microbiota in young infants with RSV infection is marked by an overrepresentation of the genus Haemophilus. We present that this bacterium is associated with viral load and mucosal CXCL8 responses, both which are involved in RSV disease pathogenesis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40168-017-0395-y) contains supplementary material, which is available to authorized users.
has issue date	2018-01-11(xsd:dateTime)
bibo:doi	10.1186/s40168-017-0395-y
bibo:pmid	29325581
has license	cc-by
sha1sum (hex)	3a39684ab2bd22b39597a985ed3c57794a941a82
schema:url	https://doi.org/10.1186/s40168-017-0395-y
resource representing a document's title	Haemophilus is overrepresented in the nasopharynx of infants hospitalized with RSV infection and associated with increased viral load and enhanced mucosal CXCL8 responses
has PubMed Central identifier	PMC5765694
has PubMed identifier	29325581
schema:publication	Microbiome
resource representing a document's body	covid:3a39684ab2bd22b39597a985ed3c57794a941a82#body_text
is schema:about of	named entity 'INFANTS' named entity 'levels' named entity 'disease' named entity 'mucosal' named entity '28I' named entity 'SUGGEST' named entity 'SEVERE DISEASE' named entity 'EFFECT' named entity 'NASOPHARYNGEAL' named entity 'YEARS' named entity 'USING' named entity 'IMPORTANT' named entity 'GENE SEQUENCING' named entity 'DISEASE' named entity 'CYTOKINE ' named entity 'MICROBIOTA' named entity 'VIRAL LOAD' named entity 'DETERMINED BY' named entity 'STUDIES' named entity 'HEALTHY' named entity 'INFANTS' named entity 'SMALL' named entity 'PREVIOUS' named entity 'LEVELS' named entity 'RSV INFECTION' named entity 'AGE' named entity 'UPPER RESPIRATORY TRACT' named entity 'MICROBIOME' named entity 'IL6' named entity 'MARKER GENE' named entity 'VIRAL LOAD' named entity 'ENHANCED' named entity 'ALMOST ALL' named entity 'PERCENTAGE' named entity 'RESPONSES' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'DEVELOPMENT' named entity 'MMP9' named entity 'PATHOPHYSIOLOGY' named entity 'NASOPHARYNX' named entity 'RSV INFECTION' named entity 'HOSPITALIZED' named entity 'MUCOSAL' named entity 'INCREASED' named entity 'HAEMOPHILUS' named entity 'ASSOCIATED WITH' named entity 'CXCL8' named entity 'MUCOSAL INFLAMMATION' named entity 'MATCHED' named entity 'DIFFERENT' named entity 'CXCL10' named entity 'RSV' named entity 'MEASURED' named entity 'BACKGROUND' named entity 'RELATION' named entity 'CCL5' named entity 'DISEASE SEVERITY' named entity 'RESPONSES' named entity 'HOST' named entity 'DEVELOPS' named entity 'MUCOSAL' named entity '16S RRNA' named entity 'ELISA' named entity 'MONTHS' named entity 'INFECTED' named entity 'CXCL8' named entity 'QPCR' named entity 'DETERMINE' covid:arg/3a39684ab2bd22b39597a985ed3c57794a941a82 named entity 'relation' named entity 'MMP9' named entity 'sequencing'

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