About: Human bocavirus 1 infection of CACO-2 cell line cultures

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human bocavirus 1 infection of CACO-2 cell line cultures
Creator	Lucía, María Adamo, Angelo, Agustin Ghietto, Ana Toigo, D Viale, María
Source	Elsevier; Medline; PMC
abstract	Abstract Human bocavirus 1 (HBoV1) is a parvovirus associated with pneumonia in infants. It has been detected in different tissues, including colorectal tumors. In this study, we investigated whether Caco-2 cell line, derived from human colon cancer, can be utilized as a model for HBoV1 replication. We demonstrate HBoV1 replication in Caco-2 cultures supplemented with DEAE-dextran after inoculation with respiratory material from infected patients presenting with acute respiratory infection. A viral cycle of rapid development is displayed. However, in spite of HBoV1 DNA 4-fold increment in the supernatants and monolayers by day 1, evidencing that the system allows the virus genome replication after the entry occurred, infectious progeny particles were not produced. These results are consistent with an infection that is limited to a single growth cycle, which can be associated to mutations in the NS1 and VP1/VP2 regions of HBoV1 genome. Further research will contribute to fully elucidate these observations.
has issue date	2017-10-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2017.07.034
bibo:pmid	28777951
has license	els-covid
sha1sum (hex)	39d433efc7ccd32c834eeda90ee9da4a4d795097
schema:url	https://doi.org/10.1016/j.virol.2017.07.034
resource representing a document's title	Human bocavirus 1 infection of CACO-2 cell line cultures
has PubMed Central identifier	PMC7172243
has PubMed identifier	28777951
schema:publication	Virology
resource representing a document's body	covid:39d433efc7ccd32c834eeda90ee9da4a4d795097#body_text
is schema:about of	named entity 'cycle' named entity 'genome' named entity 'limited' named entity 'regions' named entity 'spite' named entity 'fold' named entity 'acute respiratory infection' named entity 'colon' named entity 'Caco-2' named entity 'particles' named entity 'CACO-2' named entity 'DEAE-dextran' named entity 'colorectal tumors' named entity 'Caco-2' named entity 'Human bocavirus' named entity 'parvovirus' named entity 'virus genome' named entity 'supernatants' named entity 'cell line' named entity 'PCR' named entity 'EMEM' named entity 'viral particles' named entity 'virus' named entity 'supernatants' named entity 'DEAE-dextran' named entity 'protein' named entity 'infection' named entity 'airway epithelium' named entity 'EDTA' named entity 'nucleic acids' named entity 'nasopharyngeal aspirate' named entity 'genome' named entity 'inoculation' named entity 'picornaviruses' named entity 'tumor' named entity 'incubation' named entity 'virus' named entity 'trypsin' named entity 'Caco-2' named entity 'FITC' named entity 'Influenza virus' named entity 'penicillin' named entity '37°C' named entity 'supernatant' named entity 'antibodies' named entity 'nuclear membrane' named entity 'hpi' named entity 'genome' named entity 'supernatants' named entity 'transcription factor' named entity 'virus' named entity 'Body Fluid' named entity 'viral protein' named entity 'immunofluorescence' named entity 'Caco-2' named entity 'inoculation' named entity 'viral particles' named entity 'innate immune response' named entity 'anti-bodies' named entity 'protein' named entity 'IgG antibodies' named entity 'coding sequence' named entity 'immunofluorescence assays' named entity 'penicillin' named entity 'polymer' named entity 'cytopathic effect' named entity 'dextran' named entity 'virus' named entity 'supernatant' named entity 'mutation' named entity 'respiratory epithelium' named entity 'negative control' named entity 'culture medium' named entity 'Caco-2 cells' named entity 'HepG2' named entity 'viral load'

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