About: Covid-19 and the cardiovascular system: a comprehensive review

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Covid-19 and the cardiovascular system: a comprehensive review
Creator	Azevedo, Rafael Ferreira, Leão Gonçalves De Hollanda, Victor Gopp Botelho, Bruna João, • Junqueira De Andrade, Zarur Letícia, • Lilienwald Oei, Min Mello, Souza Muxfeldt, Elizabeth Si, Stephanie Tomás, • Villa, Leonardo
source	Medline; PMC
abstract	Cardiac injury in patients infected with the novel Coronavirus (COVID-19) seems to be associated with higher morbimortality. We provide a broad review of the clinical evolution of COVID-19, emphasizing its impact and implications on the cardiovascular system. The pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by overproduction of inflammatory cytokines (IL-6 and TNF-α) leading to systemic inflammation and multiple organ dysfunction syndrome, acutely affecting the cardiovascular system. Hypertension (56.6%) and diabetes (33.8%) are the most prevalent comorbidities among individuals with COVID-19, who require hospitalization. Furthermore, cardiac injury, defined as elevated us-troponin I, significantly relates to inflammation biomarkers (IL-6 and C-reactive protein (CRP), hyperferritinemia, and leukocytosis), portraying an important correlation between myocardial injury and inflammatory hyperactivity triggered by viral infection. Increased risk for myocardial infarction, fulminant myocarditis rapidly evolving with depressed systolic left ventricle function, arrhythmias, venous thromboembolism, and cardiomyopathies mimicking STEMI presentations are the most prevalent cardiovascular complications described in patients with COVID-19. Moreover, SARS-CoV-2 tropism and interaction with the RAAS system, through ACE2 receptor, possibly enhances inflammation response and cardiac aggression, leading to imperative concerns about the use of ACEi and ARBs in infected patients. Cardiovascular implications result in a worse prognosis in patients with COVID-19, emphasizing the importance of precocious detection and implementation of optimal therapeutic strategies.
has issue date	2020-07-27(xsd:dateTime)
bibo:doi	10.1038/s41371-020-0387-4
bibo:pmid	32719447
has license	no-cc
sha1sum (hex)	39aa33894eaa2f8ee51f82fd19d9801c7fab97cc
schema:url	https://doi.org/10.1038/s41371-020-0387-4
resource representing a document's title	Covid-19 and the cardiovascular system: a comprehensive review
has PubMed Central identifier	PMC7384729
has PubMed identifier	32719447
schema:publication	J Hum Hypertens
resource representing a document's body	covid:39aa33894eaa2f8ee51f82fd19d9801c7fab97cc#body_text
is schema:about of	named entity 'individuals' named entity 'precocious' named entity 'CRP' named entity 'complications' named entity 'inflammatory' named entity 'cardiovascular system' named entity 'Covid-19' named entity 'CARDIOVASCULAR SYSTEM' named entity 'DEPRESSED' named entity 'TNF-' named entity 'NOVEL CORONAVIRUS' named entity 'AGGRESSION' named entity 'BIOMARKERS' named entity 'AFFECTING' named entity 'PREVALENT' named entity 'OPTIMAL' named entity 'PROVIDE' named entity 'HYPERACTIVITY' named entity 'POSSIBLY' named entity 'MYOCARDIAL INFARCTION' named entity 'infected' named entity 'patients' named entity 'pathophysiology' named entity 'hyperferritinemia' named entity 'cardiovascular system' named entity 'risk' named entity 'arrhythmias' named entity 'TNF-α' named entity 'patients' named entity 'inflammation' named entity 'COVID-19' named entity 'patients' named entity 'comorbidities' named entity 'broad' named entity 'imperative' named entity 'systemic inflammation' named entity 'IL-6' named entity 'cardiovascular complications' named entity 'Coronavirus' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'COVID' named entity 'fulminant' named entity 'cardiovascular' named entity 'TNF-α' named entity 'cardiomyopathies' named entity 'Hypertension' named entity 'comorbidities' named entity 'inflammation' named entity 'troponin' named entity 'Covid-19' named entity 'host cells' named entity 'inflammatory process' named entity 'acute myocardial injury' named entity 'severe pneumonia' named entity 'myocarditis' named entity 'furin' named entity 'molecule' named entity 'COVID' named entity 'antivirals' named entity 'COVID' named entity 'troponin' named entity 'SARS-CoV-2' named entity 'virus' named entity 'RNA translation' named entity 'upper respiratory tract infection' named entity 'delayed rectifier' named entity 'brain natriuretic peptide' named entity 'pathophysiological' named entity 'hypercoagulability'

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