About: Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels
Creator	Wang, Jin-Ling Ren-Qiang, Liu Wang, Jin-Liang Yu, Shao Zhang Hui-Lei, Zhi-Gao, Bu Zhi-Yuan, Wen
source	Elsevier; Medline; PMC
abstract	Abstract Middle East respiratory syndrome coronavirus (MERS-CoV), a member of the Coronaviridae family, is the causative pathogen for MERS that is characterized by high fever, pneumonia, acute respiratory distress syndrome (ARDS), as well as extrapulmonary manifestations. Currently, there are no approved treatment regimens or vaccines for MERS. Here, we generated recombinant nonvirulent Newcastle disease virus (NDV) LaSota strain expressing MERS-CoV S protein (designated as rLa-MERS-S), and evaluated its immunogenicity in mice and Bactrian camels. The results revealed that rLa-MERS-S showed similar growth properties to those of LaSota in embryonated chicken eggs, while animal immunization studies showed that rLa-MERS-S induced MERS-CoV neutralizing antibodies in mice and camels. Our findings suggest that recombinant rLa-MERS-S may be a potential MERS-CoV veterinary vaccine candidate for camels and other animals affected by MERS.
has issue date	2017-10-31(xsd:dateTime)
bibo:doi	10.1016/s2095-3119(17)61660-5
bibo:pmid	32288953
has license	els-covid
sha1sum (hex)	399ad090293d88da72a192acfa03c4e77cda6d9b
schema:url	https://doi.org/10.1016/s2095-3119%2817%2961660-5
resource representing a document's title	Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels
has PubMed Central identifier	PMC7128255
has PubMed identifier	32288953
schema:publication	Journal of Integrative Agriculture
resource representing a document's body	covid:399ad090293d88da72a192acfa03c4e77cda6d9b#body_text
is schema:about of	named entity 'MERS' named entity 'causative' named entity 'vaccine' named entity 'MERS-CoV' named entity 'LEVEL' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'NEUTRALIZING ANTIBODIES' covid:arg/399ad090293d88da72a192acfa03c4e77cda6d9b named entity 'ELICITS' named entity 'FAMILY' named entity 'HIGH FEVER' named entity 'TREATMENT' named entity 'PATHOGEN' named entity 'STUDIES' named entity 'CHICKEN' named entity 'GROWTH' named entity 'IMMUNIZATION' named entity 'HIGH' named entity 'SIMILAR' named entity 'IMMUNOGENICITY' named entity 'PROTEIN ' named entity 'INDUCED' named entity 'MAY BE A' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'ANIMAL' named entity 'OUR' named entity 'STRAIN' named entity 'RLA' named entity 'BASED' named entity 'VACCINE' named entity 'MERS' named entity 'VACCINES' named entity 'MICE' named entity 'MEMBER OF' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'AFFECTED' named entity 'CANDIDATE' named entity 'CAMELS' named entity 'MERS-COV' named entity 'RECOMBINANT' named entity 'CORONAVIRIDAE' named entity 'HERE' named entity 'RESULTS' named entity 'EVALUATED' named entity 'CURRENTLY' named entity 'APPROVED' named entity 'VETERINARY VACCINE' named entity 'GENERATED' named entity 'FINDINGS' named entity 'PROPERTIES' named entity 'VACCINE CANDIDATE' named entity 'CHARACTERIZED' named entity 'NEUTRALIZING ANTIBODIES' named entity 'ITS' named entity 'OTHER ANIMALS' named entity 'EGGS' named entity 'CAMELS' named entity 'REVEALED' named entity 'MANIFESTATIONS' named entity 'REGIMENS' named entity 'POTENTIAL' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'PNEUMONIA' named entity 'MERS-COV S PROTEIN' named entity 'SUGGEST' named entity 'animal' named entity 'mice' named entity 'vaccines' named entity 'strain' named entity 'Bactrian' named entity 'embryonated' named entity 'treatment regimens' named entity 'acute respiratory distress syndrome' named entity 'immunogenicity' named entity 'MERS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software