About: Antibody to severe acute respiratory syndrome (SARS)-associated coronavirus spike protein domain 2 cross-reacts with lung epithelial cells and causes cytotoxicity

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About: Antibody to severe acute respiratory syndrome (SARS)-associated coronavirus spike protein domain 2 cross-reacts with lung epithelial cells and causes cytotoxicity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antibody to severe acute respiratory syndrome (SARS)-associated coronavirus spike protein domain 2 cross-reacts with lung epithelial cells and causes cytotoxicity
Creator	Wang, H Fang, Y Kuo, Y Lin, C Lin, Y Shieh, C Hwa, K Lei, H Liao, P Su, I Yeh, T Yen, ¶
Source	Medline; PMC
abstract	Both viral effect and immune-mediated mechanism are involved in the pathogenesis of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection. In this study, we showed that in SARS patient sera there were autoantibodies (autoAbs) that reacted with A549 cells, the type-2 pneumocytes, and that these autoAbs were mainly IgG. The autoAbs were detectable 20 days after fever onset. Tests of non-SARS-pneumonia patients did not show the same autoAb production as in SARS patients. After sera IgG bound to A549 cells, cytotoxicity was induced. Cell cytotoxicity and the anti-epithelial cell IgG level were positively correlated. Preabsorption and binding assays indicated the existence of cross-reactive epitopes on SARS-CoV spike protein domain 2 (S2). Furthermore, treatment of A549 cells with anti-S2 Abs and IFN-γ resulted in an increase in the adherence of human peripheral blood mononuclear cells to these epithelial cells. Taken together, we have demonstrated that the anti-S2 Abs in SARS patient sera cause cytotoxic injury as well as enhance immune cell adhesion to epithelial cells. The onset of autoimmune responses in SARS-CoV infection may be implicated in SARS pathogenesis.
has issue date	2005-09-01(xsd:dateTime)
bibo:doi	10.1111/j.1365-2249.2005.02864.x
bibo:pmid	16045740
has license	bronze-oa
sha1sum (hex)	398f12b205776606e831fedbd82e86b47946fb0f
schema:url	https://doi.org/10.1111/j.1365-2249.2005.02864.x
resource representing a document's title	Antibody to severe acute respiratory syndrome (SARS)-associated coronavirus spike protein domain 2 cross-reacts with lung epithelial cells and causes cytotoxicity
has PubMed Central identifier	PMC1809466
has PubMed identifier	16045740
schema:publication	Clinical and Experimental Immunology
resource representing a document's body	covid:398f12b205776606e831fedbd82e86b47946fb0f#body_text
is schema:about of	named entity 'acute' named entity 'sera' named entity 'enhance' named entity 'protein domain' named entity 'cell' named entity 'level' named entity 'Tests' named entity 'BOUND' named entity 'IMMUNE-MEDIATED' covid:arg/398f12b205776606e831fedbd82e86b47946fb0f named entity 'epitopes' named entity 'assays' named entity 'adherence' named entity 'infection' named entity 'A549' named entity 'existence' named entity 'onset' named entity 'Cell' named entity 'cytotoxicity' named entity 'pathogenesis' named entity 'cytotoxicity' named entity 'IgG' named entity 'peripheral blood mononuclear cells' named entity 'epitopes' named entity 'A549' named entity 'infection' named entity 'IgG' named entity 'immune-mediated' named entity 'cytotoxicity' named entity 'A549' named entity 'SARS' named entity 'epithelial cells' named entity 'severe acute respiratory syndrome' named entity 'cytotoxicity' named entity 'epithelial cells' named entity 'lung' named entity 'Antibody' named entity 'SigmaPlot' named entity 'Walkersville' named entity 'Sunnyvale' named entity 'immune-mediated' named entity 'NCBI' named entity 'Taiwan' named entity 'IPTG' named entity 'aldo-keto reductase' named entity 'A549' named entity 'PBMCs' named entity 'cell-mediated' named entity 'SARS-CoV' named entity 'A549' named entity 'cytotoxicity assay' named entity 'statistically significant' named entity 'epitope' named entity 'goat' named entity 'SARS' named entity 'pneumonia' named entity 'A549' named entity 'alveolar walls' named entity 'SARS' named entity 'epithelial cell' named entity 'peptides' named entity 'SARS' named entity 'SARS-CoV' named entity 'IgA' named entity 'alveolar' named entity 'PDB' named entity 'viral proteins' named entity 'spike proteins' named entity 'human genome' named entity 'adhesion'

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