About: Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus

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About: Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus
Creator	Xie, Zhengde Zhu, Ping Duan, Yueqiang Gu, Hongjing Han, Lina Lai, Chengcai Li, Ruisheng Li, Tieling Wang, Keyu Wang, Xiliang Wang, Zhouhai Xing, Li Yang, Penghui Yang, Xiaolan Zhang, Peirui Zhang, Shaogeng Zhao, Zhongpeng Yu, Jane
source	Medline; PMC
abstract	Respiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory illness in infants and young children, but the underlying mechanisms responsible for viral pathogenesis have not been fully elucidated. To date, no drugs or vaccines have been employed to improve clinical outcomes for RSV-infected patients. In this paper, we report that angiotensin-converting enzyme-2 (ACE2) protected against severe lung injury induced by RSV infection in an experimental mouse model and in pediatric patients. Moreover, ACE2 deficiency aggravated RSV-associated disease pathogenesis, mainly by its action on the angiotensin II type 1 receptor (AT1R). Furthermore, administration of a recombinant ACE2 protein alleviated the severity of RSV-induced lung injury. These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury, and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease.
has issue date	2016-01-27(xsd:dateTime)
bibo:doi	10.1038/srep19840
bibo:pmid	26813885
has license	cc-by
sha1sum (hex)	39855ca915f908855de8577baf009e5b1acf5f5c
schema:url	https://doi.org/10.1038/srep19840
resource representing a document's title	Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus
has PubMed Central identifier	PMC4728398
has PubMed identifier	26813885
schema:publication	Sci Rep
resource representing a document's body	covid:39855ca915f908855de8577baf009e5b1acf5f5c#body_text
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