About: Human Bocavirus Prevalence In Children With Acute Gastroenteritis From Rural Communities In The Northen Region Of South Africa

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Bocavirus Prevalence In Children With Acute Gastroenteritis From Rural Communities In The Northen Region Of South Africa
Creator	Potgieter, Natasha Kabue, Jean Rikhotso, Mpumelelo Khumela, Ronewa Ndama Traoré, Afsatou Rikhotso, Casper
Source	BioRxiv; MedRxiv
abstract	Acute gastroenteritis (AGE) is a leading cause of morbidity and mortality in young children worldwide. Human Bocavirus (HBoV) is an emerging virus globally associated with diarrhea. The aim of this study was to demonstrate the prevalence of HBoV genotypes in children (≤5 years) from rural communities in South Africa (SA) suffering from AGE. A total of 141 fecal samples of children ≤5 years with acute gastroenteritis (AGE) were collected from rural Primary Health Care facilities in the Vhembe district of SA between June 2017 and July 2018. Clinical symptoms and demographic data were also recorded. A total of 102 (72%) were outpatients and 39 (28%) were hospitalized patients. Human Bocavirus (HBoV) genotypes were determined using Real-Time Multiplex PCR. DNA extracts of positive samples were confirmed by conventional PCR targeting the NS1 gene. Co-infection with other enteric viruses were determined in HBoV positive samples using Real-Time PCR. HBoV was detected in 8 (5.7%) children with AGE. Children were in the age group between 1-24 months. HBoV1 and HBoV3 genotypes were each detected in 3 (37.5%) stool samples and HBoV2 in 2 (25%) stool samples. Co-infection with other enteric viruses included Rotavirus (37.5%); Adenovirus (37.5%); Norovirus (25%) and Astrovirus (12.5%). HBoV infections could be seen as a potential emerging diarrheal pathogen in South Africa. Further studies are required to understand the role of HBoV infections in children and adults with acute gastroenteritis. Acute gastroenteritis (AGE) is recognized as a major cause for mortality in children ≤5 years of age in Africa and other developing countries. Viruses known to be involved in AGE includes Rotavirus, Norovirus, Astrovirus and Adenovirus and have been reported globally. Recently the Human Bocavirus (HBoV) have been reported in numerous studies globally as a potential cause of diarrhea. In this study, the prevalence and genetic diversity of human Bocavirus in children with AGE from rural communities in Limpopo, South Africa were investigated. In total, 141 stool samples from children ≤ 5 years with AGE were assessed for the presence of HBoV using Real-Time PCR. HBoV were detected in 8 (5.7%) patients and included 3 positive samples for HBoV1 and HBoV3 respectively and 2 positive for HBoV2. No HBoV4 were detected. Among the 8 positive HBoV samples, co-infection with other enteric viruses were found in 7 (87.5%) samples, while mono infection with HBoV alone was detected in 1 (12.5%) patient. HBoV mixed infection with Rotavirus (3/8; 37.5%); Adenovirus (3/8; 37.5%); Norovirus (2/8; 25%) and Astrovirus (1/8; 12.5%) were observed in this study. This study reported for the first time on the prevalence of human Bocavirus in children with AGE from rural communities in South Africa.
has issue date	2019-11-04(xsd:dateTime)
bibo:doi	10.1101/830281
has license	medrxiv
sha1sum (hex)	397f879e24c3147cc207a1c0f2cc84417f86d6a5
schema:url	https://doi.org/10.1101/830281
resource representing a document's title	Human Bocavirus Prevalence In Children With Acute Gastroenteritis From Rural Communities In The Northen Region Of South Africa
schema:publication	bioRxiv
resource representing a document's body	covid:397f879e24c3147cc207a1c0f2cc84417f86d6a5#body_text
is schema:about of	named entity 'REGION' named entity 'SOUTH AFRICA' named entity 'VIRUS' named entity 'Human' named entity 'genotypes' named entity 'diarrhea' named entity 'South Africa' named entity 'genotypes' named entity 'HBoV' named entity 'source of water' named entity 'Genotypes' named entity 'genotype' named entity 'control group' named entity '1/3' named entity 'Acute gastroenteritis' named entity 'nucleotide' named entity 'viral pathogens' named entity 'South Africa' named entity 'water and sanitation' named entity 'enteric viruses' named entity 'Pakistan' named entity 'South Africa' named entity '5.7%' named entity 'primers' named entity 'genotypes' named entity '1, 2' named entity 'genotypes' named entity 'virus' named entity 'asymptomatic' named entity 'infection' named entity 'July 1' named entity 'genotypes' named entity 'developing countries' named entity 'genotypes' named entity 'tap water' named entity 'scarcity of water' named entity 'abdominal pain' named entity 'Thailand' named entity 'Bio-Rad' named entity 'Adenovirus' named entity 'faecal-oral' named entity 'diarrhea' named entity 'abdominal pain' named entity 'Finland' named entity 'viral epidemiology' named entity 'denaturation' named entity 'Real-Time PCR' named entity 'gastroenteritis' named entity 'co-infection' named entity 'Human Bocavirus' named entity 'diarrhea' named entity 'personal hygiene' named entity 'contaminated water' named entity 'genotypes' named entity 'viral pathogen' named entity 'virus' named entity 'diarrhea' named entity 'PCR' named entity 'diarrhea' named entity 'Human Bocavirus' named entity 'respiratory tract infection' named entity 'gene' named entity 'acute gastroenteritis' named entity 'diarrhea' named entity 'ethidium bromide' named entity '1/3' named entity 'pathogenesis' named entity 'virus' named entity 'dehydration' named entity 'pit latrine' named entity 'cell culture' named entity 'genetic diversity' named entity 'diarrhea' named entity 'Qiagen' named entity 'hygiene' named entity 'respiratory symptoms' named entity 'Human Bocavirus' named entity 'diarrhea' named entity 'young children'

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