About: Melittin: a venom-derived peptide with promising anti-viral properties

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About: Melittin: a venom-derived peptide with promising anti-viral properties Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Melittin: a venom-derived peptide with promising anti-viral properties
Creator	Moravvej, Hamideh Memariani, Hamed Memariani, Mojtaba Shahidi-Dadras, Mohammad
Source	PMC
abstract	Despite tremendous advances in the development of anti-viral therapeutics, viral infections remain a chief culprit accounting for ongoing morbidity and mortality worldwide. Natural products, in particular animal venoms, embody a veritable cornucopia of exotic constituents, suggesting an immensurable source of anti-infective drugs. In this context, melittin, the principal constituent in the venom of the European honeybee Apis mellifera, has been demonstrated to exert anti-cancer, anti-inflammatory, anti-diabetic, anti-infective, and adjuvant properties. To our knowledge, there is no review appertaining to effects of melittin against viruses, prompting us to synopsize experimental investigations on its anti-viral activity throughout the past decades. Accumulating evidence indicates that melittin curbs infectivity of a diverse array of viruses including coxsackievirus, enterovirus, influenza A viruses, human immunodeficiency virus (HIV), herpes simplex virus (HSV), Junín virus (JV), respiratory syncytial virus (RSV), vesicular stomatitis virus (VSV), and tobacco mosaic virus (TMV). However, medication safety, different routes of administrations, and molecular mechanisms behind the anti-viral activity of melittin should be scrutinized in future studies.
has issue date	2019-08-17(xsd:dateTime)
bibo:doi	10.1007/s10096-019-03674-0
bibo:pmid	31422545
has license	no-cc
sha1sum (hex)	395b2d4b53421a4313391833f7424c9766956d8f
schema:url	https://doi.org/10.1007/s10096-019-03674-0
resource representing a document's title	Melittin: a venom-derived peptide with promising anti-viral properties
has PubMed Central identifier	PMC7224078
has PubMed identifier	31422545
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:395b2d4b53421a4313391833f7424c9766956d8f#body_text
is schema:about of	named entity 'administrations' named entity 'VSV' named entity 'ACCUMULATING' named entity 'PROPERTIES' named entity 'EXPERIMENTAL' named entity 'ACCOUNTING' named entity 'VIRUSES' named entity 'JUN' named entity 'MELITTIN' named entity 'EXERT' named entity 'VIRAL ACTIVITY' named entity 'PAST' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'ARRAY' named entity 'ongoing' named entity 'anti-viral' named entity 'anti-infective' named entity 'coxsackievirus' named entity 'human immunodeficiency virus (HIV)' named entity 'medication safety' named entity 'viruses' named entity 'herpes simplex virus (HSV)' named entity 'viral infections' named entity 'promising' named entity 'infectivity' named entity 'VSV' named entity 'viral infections' named entity 'European honeybee' named entity 'TMV' named entity 'anti-inflammatory' named entity 'viruses' named entity 'melittin' named entity 'HSV' named entity 'viruses' named entity 'anti-viral' named entity 'venom' named entity 'melittin' named entity 'human immunodeficiency virus' named entity 'GFP' named entity 'rhabdovirus' named entity 'adverse effects' named entity 'general health' named entity 'peptide' named entity 'Melittin' named entity 'glycoproteins' named entity 'single-stranded RNA' named entity 'adsorption' named entity 'lysing' named entity 'Melittin' named entity 'melittin' named entity 'virus' named entity 'Chapare' named entity 'toxicity' named entity 'melittin' named entity 'titer' named entity 'BVDV' named entity 'Metapneumovirus' named entity 'bovine' named entity 'GFP' named entity 'hemolysis' named entity 'VZV' named entity 'Vero cells' named entity 'melittin' named entity 'Kaposi's sarcoma-associated herpesvirus' named entity 'HeLa' named entity 'CCR5' named entity 'melittin' named entity 'HSV-1' named entity 'respiratory disease' named entity 'anti-viral' named entity 'positive-sense RNA' named entity 'HIV' named entity 'liposomes' named entity 'lymphoma' named entity 'amino acid residues' named entity 'xanthopterin' named entity 'fatality rate' named entity 'infectivity'

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