About: Clinical features and outcome of 2009-influenza A (H1N1) after allogeneic hematopoietic SCT

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About: Clinical features and outcome of 2009-influenza A (H1N1) after allogeneic hematopoietic SCT Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical features and outcome of 2009-influenza A (H1N1) after allogeneic hematopoietic SCT
Creator	Kaiser, L Thomas, Y Bernimoulin, M Chalandon, Y Levrat, E Mohty, B Nagy, M Passweg, J Roosnek, E Vukicevic, M
Source	PMC
abstract	The impact of the 2009 H1N1-Influenza A (H1N1) pandemic in allogeneic hematopoietic SCT recipients (allo-HSCT) is not yet well defined. Between May 2009 and May 2010, all allo-HSCTs who presented with respiratory symptoms were screened for the presence of the H1N1 virus. Oseltamivir resistance was assessed and chart reviews were performed for all cases. In all, 51 of 248 (20%) allo-HSCT recipients followed at our outpatient clinic were screened. We identified 10 patients with H1N1 infection. Close contact with children was the most commonly suspected mode of transmission. Upper and lower respiratory tract infections were present in eight and five patients, respectively. Lymphopenia (<1 G/L) was the most frequent biological abnormality. High immunosuppression was responsible for severe infection requiring mechanical ventilation associated with prolonged viral shedding in three patients who had significant comorbidities and GvHD. Two of them developed an oseltamivir-resistant strain and both patients died subsequently despite intensive therapy, resulting in a case fatality rate of 20%. In conclusion, although most allo-HSCTs had mild symptoms from H1N1 infection, severe immunosuppression and emergence of oseltamivir resistance were likely responsible for a substantial morbidity, further supporting the need for vaccination and monitoring of close contacts, especially children.
has issue date	2011-03-21(xsd:dateTime)
bibo:doi	10.1038/bmt.2011.57
bibo:pmid	21423124
has license	no-cc
sha1sum (hex)	395ae288d1c5c5e4213e56c592ee31f5b104765a
schema:url	https://doi.org/10.1038/bmt.2011.57
resource representing a document's title	Clinical features and outcome of 2009-influenza A (H1N1) after allogeneic hematopoietic SCT
has PubMed Central identifier	PMC7091841
has PubMed identifier	21423124
schema:publication	Bone Marrow Transplant
resource representing a document's body	covid:395ae288d1c5c5e4213e56c592ee31f5b104765a#body_text
is schema:about of	named entity 'Lymphopenia' named entity 'comorbidities' named entity 'patients' named entity 'emergence' named entity 'mild' named entity 'screened' named entity 'SEVERE' named entity 'HEMATOPOIETIC' named entity 'LOWER RESPIRATORY TRACT INFECTIONS' named entity 'PERFORMED' named entity 'INFECTION' named entity 'STRAIN' named entity 'patients' named entity 'assessed' named entity 'Between' named entity 'High' named entity 'HSCT' named entity 'intensive therapy' named entity 'HSCT' named entity 'comorbidities' named entity 'immunosuppression' named entity 'GvHD' named entity 'hematopoietic' named entity '2009 H1N1' named entity 'vaccination' named entity 'H1N1' named entity 'allogeneic' named entity 'Clinical features' named entity 'contact' named entity 'immunogenic' named entity 'rhinorrhoea' named entity 'prophylaxis' named entity 'GvHD' named entity 'parainfluenza' named entity 'cough' named entity 'SPSS' named entity 'fever' named entity 'immunodeficiency' named entity 'Lymphopenia' named entity 'clinical features' named entity 'LRTI' named entity 'conditioning regimen' named entity 'sore throat' named entity 'community-acquired' named entity 'mechanical ventilation' named entity 'hypoxia' named entity 'Fever' named entity 'neutrophil' named entity 'erythema' named entity 'vaccine' named entity 'WHO' named entity 'solid organ transplant' named entity 'case fatality rate' named entity 'Hematology' named entity 'ventilator' named entity 'gastrointestinal symptoms' named entity 'UPN' named entity 'lymphoproliferation' named entity 'general population' named entity 'PCR' named entity 'two-tailed test' named entity 'upper respiratory' named entity 'mechanical ventilation' named entity 'World Health Organization' named entity 'virological' named entity 'seasonal influenza' named entity 'metapneumovirus' named entity 'Lower respiratory tract infection' named entity 'antiviral treatment' named entity 'outpatient clinic' named entity 'mode of transmission' named entity 'Switzerland'

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