About: Assessing the Potential Interactions between Cellular miRNA and Arboviral Genomic RNA in the Yellow Fever Mosquito, Aedes aegypti

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About: Assessing the Potential Interactions between Cellular miRNA and Arboviral Genomic RNA in the Yellow Fever Mosquito, Aedes aegypti Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Assessing the Potential Interactions between Cellular miRNA and Arboviral Genomic RNA in the Yellow Fever Mosquito, Aedes aegypti
Creator	Chen, Chun-Hong Failloux, Anna-Bella Kohl, Alain Sreenu, Vattipally Yen, Pei-Shi
Source	PMC
abstract	Although the role of exogenous small interfering RNA (siRNA) and P-element induced wimpy testis (PIWI)-interacting RNA (piRNA) pathways in mosquito antiviral immunity is increasingly better understood, there is still little knowledge regarding the role of mosquito cellular microRNA (miRNA). Identifying direct interactions between the mosquito miRNAs and the RNA genome of arboviruses and choosing the relevant miRNA candidates to explore resulting antiviral mechanisms are critical. Here, we carried out genomic analyses to identify Aedes aegypti miRNAs that potentially interact with various lineages and genotypes of chikungunya, dengue, and Zika viruses. By using prediction tools with distinct algorithms, several miRNA binding sites were commonly found within different genotypes/and or lineages of each arbovirus. We further analyzed those miRNAs that could target more than one arbovirus, required a low energy threshold to form miRNA-viralRNA (vRNA) complexes, and predicted potential RNA structures using RNAhybrid software. We predicted miRNA candidates that might participate in regulating arboviral replication in Ae. aegypti. Even without any experimental validation, which should be done as a next step, this study can shed further light on the role of miRNA in mosquito innate immunity and targets for future studies.
has issue date	2019-06-10(xsd:dateTime)
bibo:doi	10.3390/v11060540
bibo:pmid	31185697
has license	cc-by
sha1sum (hex)	393091a75a8617bf9fd5127a834c16743a9e89cd
schema:url	https://doi.org/10.3390/v11060540
resource representing a document's title	Assessing the Potential Interactions between Cellular miRNA and Arboviral Genomic RNA in the Yellow Fever Mosquito, Aedes aegypti
has PubMed Central identifier	PMC6631873
has PubMed identifier	31185697
schema:publication	Viruses
resource representing a document's body	covid:393091a75a8617bf9fd5127a834c16743a9e89cd#body_text
is schema:about of	named entity 'CELLULAR' named entity 'miRNA' named entity 'identify' named entity 'light' named entity 'energy' named entity 'predicted' named entity 'direct' named entity 'chikungunya' named entity 'study' named entity 'validation' named entity 'miRNA' named entity 'AEDES AEGYPTI' named entity 'SOFTWARE' covid:arg/393091a75a8617bf9fd5127a834c16743a9e89cd named entity 'ALGORITHMS' named entity 'BETTER' named entity 'INTERACTING' named entity 'YELLOW FEVER MOSQUITO' named entity 'TARGET' named entity 'ANALYZED' named entity 'MECHANISMS' named entity 'CHOOSING' named entity 'REQUIRED' named entity 'ZIKA' named entity 'INDUCED' named entity 'ARBOVIRUS' named entity 'LITTLE' named entity 'BINDING SITES' named entity 'HERE' named entity 'TO IDENTIFY' named entity 'LIGHT' named entity 'PREDICTION' named entity 'RNA' named entity 'MIRNA' named entity 'LOW ENERGY' named entity 'OF EACH' named entity 'THRESHOLD' named entity 'STEP' named entity 'IDENTIFYING' named entity 'TESTIS' named entity 'ASSESSING' named entity 'POTENTIAL' named entity 'DIFFERENT' named entity 'STUDY' named entity 'RNA' named entity 'RELEVANT' named entity 'EXPERIMENTAL' named entity 'DENGUE' named entity 'INNATE IMMUNITY' named entity 'TARGETS' named entity 'MIRNAS' named entity 'MORE THAN ONE' named entity 'VALIDATION' named entity 'MOSQUITO' named entity 'STUDIES' named entity 'CARRIED' named entity 'DISTINCT' named entity 'INTERACTIONS' named entity 'FUTURE' named entity 'FOUND' named entity 'CRITICAL' named entity 'VARIOUS' named entity 'UNDERSTOOD' named entity 'REGULATING' named entity 'VIRUSES' named entity 'IMMUNITY' named entity 'INTERACT' named entity 'CHIKUNGUNYA' named entity 'GENOMIC' named entity 'COMPLEXES' named entity 'VIRALRNA' named entity 'EXOGENOUS' named entity 'RESULTING' named entity 'KNOWLEDGE' named entity 'MICRORNA' named entity 'GENOTYPES' named entity 'TOOLS'

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