About: Clinical relevance of necrotizing change in patients with community‐acquired pneumonia

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About: Clinical relevance of necrotizing change in patients with community‐acquired pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical relevance of necrotizing change in patients with community‐acquired pneumonia
Creator	Cha, Seung-Ick Kim, Chang-Ho Lee, Jaehee Lee, Shin-Yup Lim, Jae-Kwang Park, Jae-Yong Seo, Hyewon Shin, Kyung-Min Yoo, Seung-Soo Lee, Won-Kee
Source	PMC
abstract	BACKGROUND AND OBJECTIVE: Few studies have analysed a large number of patients with necrotizing pneumonia (NP) diagnosed based on computed tomography (CT) scans. The aim of the present study was to document the incidence and clinical features of NP in patients with community‐acquired pneumonia (CAP). METHODS: This retrospective study was conducted on CAP patients who had been admitted to a tertiary referral centre and who had available enhanced CT scan images. Patients were allocated into NP and non‐NP groups, and they were compared with respect to various clinical variables. RESULTS: Of the 830 patients included in the present study, necrotizing change was observed in 103 patients (12%). Patients with NP experienced more symptoms of pneumonia, had higher blood levels of inflammatory markers and more often required pleural drainage compared to patients with non‐NP. Although the use of mechanical ventilation, vasopressor infusion, 30‐day mortality, in‐hospital mortality and clinical deterioration did not differ between the NP and non‐NP groups, the median length of hospital stay (LOS) was significantly longer in the NP group. Multivariate analysis using Cox proportional hazards model showed that necrotizing change independently predicted LOS in patients with CAP. CONCLUSION: NP affects approximately one‐tenth of hospitalized CAP patients. It may be associated with more severe clinical manifestations and may increase the need for pleural drainage. NP was found to be an independent predictor of LOS, but not of mortality in CAP patients.
has issue date	2016-11-08(xsd:dateTime)
bibo:doi	10.1111/resp.12943
bibo:pmid	27862706
has license	no-cc
sha1sum (hex)	37f16359199ca5e6f0399a1fb30577e9864129b0
schema:url	https://doi.org/10.1111/resp.12943
resource representing a document's title	Clinical relevance of necrotizing change in patients with community‐acquired pneumonia
has PubMed Central identifier	PMC7169103
has PubMed identifier	27862706
schema:publication	Respirology
resource representing a document's body	covid:37f16359199ca5e6f0399a1fb30577e9864129b0#body_text
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