About: Development of inhibitors in the ubiquitination cascade

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Development of inhibitors in the ubiquitination cascade Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development of inhibitors in the ubiquitination cascade
Creator	Zhang, Wei Sidhu, Sachdev
Source	Elsevier; Medline; PMC
abstract	The ubiquitin proteasome system (UPS) is essential in regulating myriad aspects of protein functions. It is therefore a fundamentally important regulatory mechanism that impacts most if not all aspects of cellular processes. Indeed, malfunction of UPS components is implicated in human diseases such as neurodegenerative and immunological disorders and many cancers. The success of proteasome inhibitors in cancer therapy suggests that modulating enzymes in the ubiquitination cascade would be clinically important for therapeutic benefits. In this review, we summarize advances in developing inhibitors of a variety of UPS components. In particular, we highlight recent work done on the protein engineering of ubiquitin as modulators of the UPS, a novel approach that may shed light on innovative drug discovery in the future.
has issue date	2014-01-21(xsd:dateTime)
bibo:doi	10.1016/j.febslet.2013.11.003
bibo:pmid	24239534
has license	no-cc
sha1sum (hex)	37c28f272e4f6af26a0d905ea2fc73332acc64d7
schema:url	https://doi.org/10.1016/j.febslet.2013.11.003
resource representing a document's title	Development of inhibitors in the ubiquitination cascade
has PubMed Central identifier	PMC7094371
has PubMed identifier	24239534
schema:publication	FEBS Lett
resource representing a document's body	covid:37c28f272e4f6af26a0d905ea2fc73332acc64d7#body_text
is schema:about of	named entity 'impacts' named entity 'cascade' named entity 'cancer therapy' named entity 'inhibitors' named entity 'UPS' named entity 'MALFUNCTION' named entity 'MODULATING' named entity 'APPROACH' named entity 'WORK' named entity 'PROTEIN ENGINEERING' named entity 'MECHANISM' named entity 'PARTICULAR' named entity 'REVIEW' named entity 'FUNCTIONS' named entity 'PROTEASOME INHIBITORS' named entity 'VARIETY' named entity 'ESSENTIAL' named entity 'FUTURE' named entity 'ENZYMES' named entity 'DEVELOPMENT' named entity 'RECENT' named entity 'UPS' named entity 'HUMAN DISEASES' named entity 'DRUG DISCOVERY' named entity 'SUCCESS' named entity 'CANCER THERAPY' named entity 'MODULATORS' named entity 'CANCERS' named entity 'DISORDERS' named entity 'NOVEL' named entity 'INHIBITORS' named entity 'CASCADE' named entity 'UBIQUITINATION' named entity 'INHIBITORS' named entity 'CELLULAR PROCESSES' named entity 'REGULATING' named entity 'BENEFITS' named entity 'THERAPEUTIC' named entity 'IMPORTANT' named entity 'SYSTEM' named entity 'CASCADE' named entity 'COMPONENTS' named entity 'LIGHT' named entity 'UBIQUITINATION' named entity 'REGULATORY' named entity 'IMMUNOLOGICAL' named entity 'IMPACTS' named entity 'UBIQUITIN' named entity 'PROTEASOME' named entity 'DEVELOPING' named entity 'PROTEIN ' covid:arg/37c28f272e4f6af26a0d905ea2fc73332acc64d7 named entity 'immunological' named entity 'future' named entity 'regulating' named entity 'immunological disorders' named entity 'proteasome inhibitors' named entity 'ubiquitination' named entity 'ternary complex' named entity 'covalently' named entity 'USP' named entity 'UPS' named entity 'UBE2M' named entity 'cancer cells' named entity 'clinical treatment' named entity 'Structural studies' named entity 'polypeptides' named entity 'OTUB1' named entity 'inhibit apoptosis' named entity 'catalytic reaction' named entity 'thiol' named entity 'protein' named entity 'Novartis' named entity 'UBC' named entity 'PYR-41' named entity 'secondary structural elements' named entity 'NAE' named entity 'p53' named entity 'USP7' named entity 'sedative'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software