About: Mechanisms of action of ribavirin against distinct viruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mechanisms of action of ribavirin against distinct viruses
Creator	Cameron, Craig Graci, Jason
Source	Medline; PMC
abstract	The nucleoside analogue ribavirin has antiviral activity against many distinct viruses both in vitro and in vivo. Five distinct mechanisms have been proposed to explain the antiviral properties of ribavirin. These include both indirect mechanisms (inosine monophosphate dehydrogenase inhibition, immunomodulatory effects) and direct mechanisms (interference with RNA capping, polymerase inhibition, lethal mutagenesis). Recent concerns about bioterrorism have renewed interest in exploring the antiviral activity of ribavirin against unique viruses. In this paper, we review the proposed mechanisms of action with emphasis on recent discoveries, as well as the implications of ribavirin resistance. Evidence exists to support each of the five proposed mechanisms of action, and distinct virus/host combinations may preferentially favour one or more of these mechanisms during antiviral therapy. Copyright © 2005 John Wiley & Sons, Ltd.
has issue date	2005-11-15(xsd:dateTime)
bibo:doi	10.1002/rmv.483
bibo:pmid	16287208
has license	no-cc
sha1sum (hex)	378afbb3a5c1ed3d35a2d8dca06f131a41e0329e
schema:url	https://doi.org/10.1002/rmv.483
resource representing a document's title	Mechanisms of action of ribavirin against distinct viruses
has PubMed Central identifier	PMC7169142
has PubMed identifier	16287208
schema:publication	Rev Med Virol
resource representing a document's body	covid:378afbb3a5c1ed3d35a2d8dca06f131a41e0329e#body_text
is schema:about of	named entity 'activity' named entity 'RNA' named entity 'direct' named entity 'exploring' named entity 'combinations' named entity 'THESE' named entity 'DIRECT' named entity 'LETHAL' named entity 'ribavirin' named entity 'action' named entity 'Evidence' named entity 'vivo' named entity 'antiviral' named entity 'action' named entity 'implications' named entity 'ribavirin' named entity 'ribavirin' named entity 'viruses' named entity 'RNA' named entity 'to-5' named entity 'antiviral effect' named entity 'virus' named entity 'vaccinia virus' named entity 'NS5B' named entity 'carboxamide' named entity 'adenosine' named entity 'human Action' named entity 'uncompetitive inhibitor' named entity 'ribavirin' named entity 'haemorrhagic fever with renal syndrome' named entity 'proofreading' named entity 'enzyme' named entity 'immunomodulation' named entity 'RNA' named entity 'metabolites' named entity 'virus' named entity 'IMPDH' named entity 'N-terminal fragment' named entity 'antiviral therapy' named entity 'ribonucleotide' named entity 'NS5B' named entity 'RNA viruses' named entity 'viral load' named entity 'viral load' named entity 'base-pairing' named entity 'ribonucleotide reductase' named entity 'erythrocytes' named entity 'viruses' named entity 'virus replication' named entity 'Vero' named entity 'hepatitis B virus' named entity 'GTP' named entity 'GTP' named entity 'virus' named entity 'eIF4E' named entity 'quasispecies' named entity 'HCV' named entity 'infection' named entity 'life cycle' named entity 'tumour necrosis factor-alpha' named entity 'ribavirin' named entity 'metabolite' named entity 'guanosine' named entity 'antivirals' named entity 'antiviral effect' named entity 'ribavirin' named entity 'plasma' named entity 'mutagen' named entity 'polymerase' named entity 'glycine' named entity 'GTP' named entity 'metabolites' named entity 'mechanism of action' named entity 'ribavirin' named entity 'potency' named entity 'X-ray crystal structure' named entity 'nucleoside analogue' named entity 'nucleotide analogue' named entity 'ribavirin' named entity 'deoxynucleotide'

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