About: Dendritic Cell-Specific Delivery of Flt3L by Coronavirus Vectors Secures Induction of Therapeutic Antitumor Immunity

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About: Dendritic Cell-Specific Delivery of Flt3L by Coronavirus Vectors Secures Induction of Therapeutic Antitumor Immunity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dendritic Cell-Specific Delivery of Flt3L by Coronavirus Vectors Secures Induction of Therapeutic Antitumor Immunity
Creator	Allgäuer, M Cervantes-Barragan, E Nussbacher, C Perez-Shibayama, C
Source	Medline; PMC
abstract	Efficacy of antitumor vaccination depends to a large extent on antigen targeting to dendritic cells (DCs). Here, we assessed antitumor immunity induced by attenuated coronavirus vectors which exclusively target DCs in vivo and express either lymphocyte- or DC-activating cytokines in combination with a GFP-tagged model antigen. Tracking of in vivo transduced DCs revealed that vectors encoding for Fms-like tyrosine kinase 3 ligand (Flt3L) exhibited a higher capacity to induce DC maturation compared to vectors delivering IL-2 or IL-15. Moreover, Flt3L vectors more efficiently induced tumor-specific CD8(+) T cells, expanded the epitope repertoire, and provided both prophylactic and therapeutic tumor immunity. In contrast, IL-2- or IL-15-encoding vectors showed a substantially lower efficacy in CD8(+) T cell priming and failed to protect the host once tumors had been established. Thus, specific in vivo targeting of DCs with coronavirus vectors in conjunction with appropriate conditioning of the microenvironment through Flt3L represents an efficient strategy for the generation of therapeutic antitumor immunity.
has issue date	2013-11-28(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0081442
bibo:pmid	24312302
has license	cc-by
sha1sum (hex)	378082edc2f3e85e6cc8941c81030a70c65c7f8f
schema:url	https://doi.org/10.1371/journal.pone.0081442
resource representing a document's title	Dendritic Cell-Specific Delivery of Flt3L by Coronavirus Vectors Secures Induction of Therapeutic Antitumor Immunity
has PubMed Central identifier	PMC3842931
has PubMed identifier	24312302
schema:publication	PLoS One
resource representing a document's body	covid:378082edc2f3e85e6cc8941c81030a70c65c7f8f#body_text
is schema:about of	named entity 'antitumor' named entity 'immunity' named entity 'conjunction' named entity 'vivo' named entity 'host' named entity 'Vectors' named entity 'DENDRITIC CELL' named entity 'VECTORS' named entity 'CORONAVIRUS' named entity 'CYTOKINES' named entity 'TARGETING' named entity 'MODEL' named entity 'IN VIVO' named entity 'HERE' named entity 'ENCODING' named entity 'IL-2' named entity 'PROPHYLACTIC' named entity 'TUMOR' covid:arg/378082edc2f3e85e6cc8941c81030a70c65c7f8f named entity 'CONDITIONING' named entity 'MICROENVIRONMENT' named entity 'COMBINATION' named entity 'APPROPRIATE' named entity 'HOST' named entity 'VECTORS' named entity 'CONTRAST' named entity 'STRATEGY' named entity 'COMPARED' named entity 'SPECIFIC' named entity 'SECURES' named entity 'CD8' named entity 'TAGGED' named entity 'ANTIGEN TARGETING' named entity 'EITHER' named entity 'THERAPEUTIC' named entity 'DENDRITIC CELLS' named entity 'CAPACITY' named entity 'TARGET' named entity 'HIGHER' named entity 'CORONAVIRUS' named entity 'ANTITUMOR' named entity 'FLT3L' named entity 'DELIVERY' named entity 'THERAPEUTIC' named entity 'LOWER' named entity 'T CELL' named entity 'GENERATION' named entity 'CONJUNCTION' named entity 'VACCINATION' named entity 'FLT3L' named entity 'EXPRESS' named entity 'ASSESSED' named entity 'EXPANDED ' named entity 'INDUCED' named entity 'EFFICIENT' named entity 'TRACKING' named entity 'ACTIVATING' named entity 'IL-15' named entity 'ANTITUMOR' named entity 'REPERTOIRE' named entity 'REVEALED' named entity 'MATURATION' named entity 'LARGE EXTENT' named entity 'SPECIFIC' named entity 'PROVIDED' named entity 'DCS' named entity 'FAILED' named entity 'EFFICACY' named entity 'IMMUNITY' named entity 'TUMOR IMMUNITY' named entity 'ESTABLISHED' named entity 'T CELLS' named entity 'INDUCE' named entity 'PRIMING' named entity 'INDUCTION' named entity 'LYMPHOCYTE' named entity 'ATTENUATED' named entity 'ANTIGEN'

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