About: Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation
Creator	Adle-Biassette, Homa Arbabian, Atousa Brouland, Jean-Philippe Carosella, Edgardo Enyedi, Agnes Gélébart, Pascal Launay, Sophie Papp, Bela
source	Medline; PMC
abstract	Endoplasmic reticulum (ER) calcium homeostasis plays an essential role in cellular calcium signaling, intra-ER protein chaperoning and maturation, as well as in the interaction of the ER with other organelles. Calcium is accumulated in the ER by sarco/endoplasmic reticulum calcium ATPases (SERCA enzymes) that generate by active, ATP-dependent transport, a several thousand-fold calcium ion concentration gradient between the cytosol (low nanomolar) and the ER lumen (high micromolar). SERCA enzymes are coded by three genes that by alternative splicing give rise to several isoforms, which can display isoform-specific calcium transport characteristics. SERCA expression levels and isoenzyme composition vary according to cell type, and this constitutes a mechanism whereby ER calcium homeostasis is adapted to the signaling and metabolic needs of the cell, depending on its phenotype, its state of activation and differentiation. As reviewed here, in several normal epithelial cell types including bronchial, mammary, gastric, colonic and choroid plexus epithelium, as well as in mature cells of hematopoietic origin such as pumps are simultaneously expressed, whereas in corresponding tumors and leukemias SERCA3 expression is selectively down-regulated. SERCA3 expression is restored during the pharmacologically induced differentiation of various cancer and leukemia cell types. SERCA3 is a useful marker for the study of cell differentiation, and the loss of SERCA3 expression constitutes a previously unrecognized example of the remodeling of calcium homeostasis in tumors.
has issue date	2020-05-09(xsd:dateTime)
bibo:doi	10.3390/ijms21093351
bibo:pmid	32397400
has license	cc-by
sha1sum (hex)	37590e21ca5232a8c219041f74426a3713bf26a9
schema:url	https://doi.org/10.3390/ijms21093351
resource representing a document's title	Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation
has PubMed Central identifier	PMC7247589
has PubMed identifier	32397400
schema:publication	Int J Mol Sci
resource representing a document's body	covid:37590e21ca5232a8c219041f74426a3713bf26a9#body_text
is schema:about of	named entity 'expression' named entity 'choroid plexus' named entity 'cytosol' named entity 'down-regulated' named entity 'SERCA' named entity 'micromolar' named entity 'leukemias' named entity 'ATPases' named entity 'gastric' named entity 'calcium signaling' named entity 'epithelial cell' named entity 'simultaneously' named entity 'pumps' named entity 'mechanism' named entity 'types' named entity 'high' named entity 'essential' named entity 'interaction' named entity 'activation' named entity 'sarco' named entity 'Calcium' named entity 'tumors' named entity 'down-regulated' named entity 'expression levels' named entity 'SERCA' named entity 'calcium' named entity 'nanomolar' named entity 'calcium ion' named entity 'hematopoietic' named entity 'calcium homeostasis' named entity 'leukemias' named entity 'calcium homeostasis' named entity 'metabolic' named entity 'tumors' named entity 'isoform' named entity 'Calcium' named entity 'Molecular Sciences' named entity 'expression' named entity 'calcium' named entity 'CD22' named entity 'choroid plexus' named entity 'carcinomas' named entity 'homeostasis' named entity 'tumors' named entity 'calcium signals' named entity 'calcium' named entity 'avidin' named entity 'heterozygous' named entity 'non-neoplastic' named entity 'APL' named entity 'Paris' named entity 'SERCA' named entity 'fully activated' named entity 'hormone receptor' named entity 'Secretion' named entity 'skeletal muscle' named entity 'RAG-1' named entity 'endoplasmic reticulum' named entity 'phenotypic' named entity 'Orai' named entity 'epithelial' named entity 'calcium pump' named entity 'isoform' named entity 'calcium channel' named entity 'three-dimensional structure' named entity 'Orai' named entity 'malignant cells' named entity 'drug repurposing' named entity 'SERCA' named entity 'bronchial epithelial cells' named entity 'protein' named entity 'mitochondrial calcium uniporter' named entity 'immunohistochemistry' named entity 'choroid plexus'

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