About: Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway

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About: Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway
Creator	Wang, Ming Yan, Jinghua Zhang, Jie Liu, Di Gao, George Guan, Zhenhong Mi, Shuofu Ye, Qinong
Source	PMC
abstract	Influenza virus contains three integral membrane proteins: haemagglutinin, neuraminidase, and matrix protein (M1 and M2). Among them, M2 protein functions as an ion channel, important for virus uncoating in endosomes of virus-infected cells and essential for virus replication. In an effort to explore potential new functions of M2 in the virus life cycle, we used yeast two-hybrid system to search for M2-associated cellular proteins. One of the positive clones was identified as human Hsp40/Hdj1, a DnaJ/Hsp40 family protein. Here, we report that both BM2 (M2 of influenza B virus) and A/M2 (M2 of influenza A virus) interacted with Hsp40 in vitro and in vivo. The region of M2-Hsp40 interaction has been mapped to the CTD1 domain of Hsp40. Hsp40 has been reported to be a regulator of PKR signaling pathway by interacting with p58(IPK) that is a cellular inhibitor of PKR. PKR is a crucial component of the host defense response against virus infection. We therefore attempted to understand the relationship among M2, Hsp40 and p58(IPK) by further experimentation. The results demonstrated that both A/M2 and BM2 are able to bind to p58(IPK)in vitro and in vivo and enhance PKR autophosphorylation probably via forming a stable complex with Hsp40 and P58(IPK), and consequently induce cell death. These results suggest that influenza virus M2 protein is involved in p58(IPK) mediated PKR regulation during influenza virus infection, therefore affecting infected-cell life cycle and virus replication.
has issue date	2010-10-01(xsd:dateTime)
bibo:doi	10.1007/s13238-010-0115-x
bibo:pmid	21204021
has license	bronze-oa
sha1sum (hex)	374c3b822d0f666408ccd08ae000d07959492bdd
schema:url	https://doi.org/10.1007/s13238-010-0115-x
resource representing a document's title	Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway
has PubMed Central identifier	PMC4875119
has PubMed identifier	21204021
schema:publication	Protein & Cell
resource representing a document's body	covid:374c3b822d0f666408ccd08ae000d07959492bdd#body_text
is schema:about of	named entity 'IPK' named entity 'virus' named entity 'neuraminidase' named entity 'virus' named entity 'interaction' named entity 'virus' named entity 'Interaction' named entity 'INFLUENZA VIRUS' named entity 'M2 PROTEIN' named entity 'UNDERSTAND' named entity 'PKR' named entity 'SEARCH' named entity 'P58' named entity 'PROBABLY' named entity 'STABLE COMPLEX' named entity 'INVOLVED' named entity 'TO BIND TO' named entity 'IN VIVO' named entity 'AUTOPHOSPHORYLATION' named entity 'M2 PROTEIN' named entity 'HOST DEFENSE' named entity 'VIRUS REPLICATION' named entity 'REGULATION' named entity 'YEAST TWO-HYBRID SYSTEM' named entity 'INFLUENZA VIRUS' named entity 'INFECTED' named entity 'PKR SIGNALING PATHWAY' named entity 'INTERACTION' named entity 'IN VITRO' named entity 'PROTEINS' named entity 'INFLUENZA B VIRUS' named entity 'IDENTIFIED' named entity 'HERE' named entity 'RELATIONSHIP' named entity 'COMPONENT' named entity 'BM2' named entity 'CONTAINS' named entity 'VIRUS INFECTION' named entity 'POTENTIAL' named entity 'ESSENTIAL' named entity 'HSP40' named entity 'REPORTED' named entity 'CLONES' named entity 'INTERACTED' named entity 'DEFENSE RESPONSE' named entity 'INHIBITOR' named entity 'IS A' named entity 'ENHANCE' named entity 'NEURAMINIDASE' named entity 'ENDOSOMES' covid:arg/374c3b822d0f666408ccd08ae000d07959492bdd named entity 'INTERACTION' named entity 'CELL LIFE CYCLE' named entity 'FUNCTIONS' named entity 'INFLUENZA A VIRUS' named entity 'AFFECTING' named entity 'IPK' named entity 'CELLS' named entity 'DNAJ' named entity 'ION CHANNEL' named entity 'VIRUS' named entity 'ASSOCIATED' named entity 'EFFORT' named entity 'INTERACTING' named entity 'INFECTED-CELL' named entity 'RESULTS' named entity 'VIRUS UNCOATING' named entity 'REPORT' named entity 'FAMILY' named entity 'INTEGRAL MEMBRANE PROTEINS' named entity 'LIFE CYCLE' named entity 'POSITIVE' named entity 'HSP40' named entity 'PKR SIGNALING PATHWAY'

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