About: Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection

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About: Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection
Creator	Jiang, Shibo Peng, Bi-Hung Wang, Lili Ying, Tianlei Algaissi, Abdullah Garron, Tania Tao, Xinrong Wang, Yanping Dimitrov, Dimiter Chien-Te, & Shankar Agrawal, Anurodh Tseng, K
source	Medline; PMC
abstract	Middle East Respiratory Syndrome coronavirus (MERS-CoV) has repeatedly caused outbreaks in the Arabian Peninsula. To date, no approved medical countermeasures (MCM) are available to combat MERS-CoV infections. Several neutralizing human monoclonal antibodies (mAbs), including m336, a germline-like human mAb, have been chosen as promising MCM for MERS-CoV. However, their clinical development has been hindered by the lack of a robust animal model that recapitulate the morbidity and mortality of human infections. We assessed the prophylactic and therapeutic efficacy of m336 by using well-characterized transgenic mice shown to be highly sensitive to MERS-CoV infection and disease. We found that mice treated with m336 prior to or post lethal MERS-CoV challenging were fully protected, compared to control mice which sufferered from profound weight loss and uniform death within days after infection. Taken together, these results support further development of m336 and other human monoclonal antibodies as potential therapeutics for MERS-CoV infection.
has issue date	2016-08-19(xsd:dateTime)
bibo:doi	10.1038/srep31629
bibo:pmid	27538452
has license	cc-by
sha1sum (hex)	371c9fd77329f6bd62e32c702dfbed1bb5ae2401
schema:url	https://doi.org/10.1038/srep31629
resource representing a document's title	Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection
has PubMed Central identifier	PMC4990914
has PubMed identifier	27538452
schema:publication	Sci Rep
resource representing a document's body	covid:371c9fd77329f6bd62e32c702dfbed1bb5ae2401#body_text
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