About: Nasal Microbiota in RSV Bronchiolitis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Nasal Microbiota in RSV Bronchiolitis
Creator	Midulla, Fabio Nenna, Raffaella Pierangeli, Alessandra Frassanito, Antonella Bonfiglio, Giulia Frasca, Federica Guerrieri, Francesca Marazzato, Massimiliano Neroni, Bruna Oliveto, Giuseppe Petrarca, Laura Schippa, Serena
source	Medline; PMC
abstract	Respiratory Syncytial Virus (RSV) is the leading cause of bronchiolitis, and the severity may be influenced by the bacterial ecosystem. Our aim was to analyze the nasal microbiota from 48 infants affected by bronchiolitis from RSV virus and 28 infants with bronchiolitis but negative for the virus. Results showed a significantly lower biodiversity in the RSV-positive group with respect to the RSV-negative group, a specific microbial profile associated with the RSV-positive group different from that observed in the negative group, and significant modifications in the relative abundance of taxa in the RSV-positive group, as well as in the RSV-A group, with respect to the negative group. Furthermore, microbial network analyses evidenced, in all studied groups, the presence of two predominant sub-networks characterized by peculiar inter- and intra-group correlation patterns as well as a general loss of connectivity among microbes in the RSV-positive group, particularly in the RSV-A group. Our results indicated that infants with more severe bronchiolitis disease, caused by RSV-A infection, present significant perturbations of both the nasal microbiota structure and the microbial relationships. Patients with a milder bronchiolitis course (RSV-B-infected and patients who have cleared the virus) presented less severe alterations.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.3390/microorganisms8050731
bibo:pmid	32414211
has license	cc-by
sha1sum (hex)	36e6b17957b776f45c6fed6c0299c88ff624cd49
schema:url	https://doi.org/10.3390/microorganisms8050731
resource representing a document's title	Nasal Microbiota in RSV Bronchiolitis
has PubMed Central identifier	PMC7284514
has PubMed identifier	32414211
schema:publication	Microorganisms
resource representing a document's body	covid:36e6b17957b776f45c6fed6c0299c88ff624cd49#body_text
is schema:about of	named entity 'infants' named entity 'taxa' named entity 'microbiota' named entity 'abundance' named entity 'bacterial' named entity 'loss' named entity 'A GROUP' named entity 'SUB-' named entity 'INTER-' named entity 'NETWORKS' named entity 'PROFILE' named entity 'SEVERE' named entity 'LOSS OF' named entity 'RESPECT' named entity 'CORRELATION' named entity 'BACTERIAL' named entity 'RSV' named entity 'nasal' named entity 'microbiota' named entity 'perturbations' named entity 'predominant' named entity 'negative' named entity 'group' named entity 'virus' named entity 'bronchiolitis' named entity 'RSV' named entity 'RSV' named entity 'virus' named entity 'correlation' named entity 'virus' named entity 'RSV' named entity 'microbiota' named entity 'bronchiolitis' named entity 'biodiversity' named entity 'infection' named entity 'RSV' named entity 'RSV' named entity 'microorganisms' named entity 'presented' named entity 'severe' named entity 'microbiota' named entity 'microbiome' named entity 'bronchiolitis' named entity 'microbiota' named entity 'microbiota' named entity 'metagenomic analysis' named entity 'microbial' named entity '25.0' named entity 'nostril' named entity 'Round Rock' named entity 'RSV' named entity 'lower respiratory tract infection' named entity 'H. influenzae' named entity 'RSV' named entity 'ecosystem' named entity 'institutional review boards' named entity 'Roche Diagnostics' named entity 'phylum' named entity 'RSV' named entity 'lymphocytes' named entity 'RSV' named entity 'S. pneumoniae' named entity 'Streptococcus' named entity 'RSV' named entity 'Rhinovirus' named entity 'RSV' named entity 'virus' named entity 'Epidemiological' named entity 'bronchiolitis' named entity 'correlation'

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