About: A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin

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About: A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin
Creator	Attar, Farnoosh Falahati, Mojtaba Sharifi, Majid Saboury, Ali Hussain, Arif Hasan, Anwarul Derakhshankhah, Hossein Mehrabi, Masoumeh Rasti, Behnam Shahpasand, Koorosh Aziz, Mohammad Paray, Ahamad Qadir, Ali
Source	Medline; PMC
abstract	The widespread antigenic changes lead to the emergence of a new type of coronavirus (CoV) called as severe acute respiratory syndrome (SARS)-CoV-2 that is immunologically different from the previous circulating species. Angiotensin-converting enzyme-2 (ACE-2) is one of the most important receptors on the cell membrane of the host cells (HCs) which its interaction with spike protein (SP) with a furin-cleavage site results in the SARS-CoV-2 invasion. Hence, in this review, we presented an overview on the interaction of ACE-2 and furin with SP. As several kinds of CoVs, from various genera, have at their S1/S2 binding site a preserved site, we further surveyed the role of furin cleavage site (FCS) on the life cycle of the CoV. Furthermore, we discussed that the small molecular inhibitors can limit the interaction of ACE-2 and furin with SP and can be used as potential therapeutic platforms to combat the spreading CoV epidemic. Finally, some ongoing challenges and future prospects for the development of potential drugs to promote targeting specific activities of the CoV were reviewed. In conclusion, this review may pave the way for providing useful information about different compounds involved in improving the effectiveness of CoV vaccine or drugs with minimum toxicity against human health. Communicated by Ramaswamy H. Sarma
has issue date	2020-04-22(xsd:dateTime)
bibo:doi	10.1080/07391102.2020.1754293
bibo:pmid	32274964
has license	no-cc
sha1sum (hex)	36abdfdc52ca14f4c2a8b6105d03b5734bd568da
schema:url	https://doi.org/10.1080/07391102.2020.1754293
resource representing a document's title	A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin
has PubMed Central identifier	PMC7189411
has PubMed identifier	32274964
schema:publication	J Biomol Struct Dyn
resource representing a document's body	covid:36abdfdc52ca14f4c2a8b6105d03b5734bd568da#body_text
is schema:about of	named entity 'protein' named entity 'surveyed' named entity 'combat' named entity 'specific' named entity 'spike' named entity 'activities' named entity 'pave' named entity 'ACE' named entity 'inhibitors' named entity 'cleavage' named entity 'COMBAT' named entity 'DIFFERENT' named entity 'PRESERVED' named entity 'REVIEWED' named entity 'cells' named entity 'therapeutic' named entity 'ACE' named entity 'targeting' named entity 'molecular' named entity 'involved' named entity 'prospects' named entity 'epidemic' named entity 'human health' named entity 'furin' named entity 'antigenic' named entity 'severe acute respiratory syndrome' named entity 'Angiotensin-converting enzyme' named entity 'ACE-2' named entity 'angiotensin-converting enzyme' named entity 'coronavirus' named entity 'furin' named entity 'cell membrane' named entity 'ACE-2' named entity 'spike protein' named entity 'cleavage' named entity 'circulating' named entity 'genera' named entity 'ACE-2' named entity 'cleavage site' named entity 'furin' named entity 'life cycle' named entity 'HCs' named entity 'furin' named entity 'host cells' named entity 'small molecular' named entity 'SARS' covid:arg/36abdfdc52ca14f4c2a8b6105d03b5734bd568da named entity 'ROLE' named entity 'spike protein' named entity 'binding site' named entity 'THE CELL' named entity 'FUTURE' named entity 'INVASION' named entity 'EPIDEMIC' named entity 'SPECIFIC' named entity 'ONE OF' named entity 'ANGIOTENSIN-CONVERTING ENZYME' named entity 'coronavirus' named entity 'SARS-CoV-2' named entity 'toxicity' named entity 'effectiveness' named entity 'site' named entity 'interaction' named entity 'site' named entity 'preserved' named entity 'human health' named entity 'host' named entity 'receptors' named entity 'cell membrane'

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