About: Novel activities of safe-in-human broad-spectrum antiviral agents

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Novel activities of safe-in-human broad-spectrum antiviral agents
Creator	Merits, Andres Evander, Magnus Hukkanen, Veijo Ianevski, Aleksandr Tenson, Tanel Zusinaite, Eva Julkunen, Ilkka Aittokallio, Tero Kakkola, Laura Kuivanen, Suvi Oksenych, Valentyn Paavilainen, Henrik Vapalahti, Olli Bergqvist, Anders Bjørås, Magnar Dumpis, Uga Kainov, Denis Kallio-Kokko, Hannimari Teppor, Mona Vitkauskiene, Astra Cox, Rebecca Nordbø, Svein Valkonen, Miia Kantele, Anu Lutsar, Irja Lysvand, Hilde Marjomaki, Varpu Telling, Kaidi Bondeson, Kåre Laajala, Mira Letjuka, Pille Metelitsa, Natalja Strand, Mårten
source	Elsevier; Medline; PMC
abstract	Abstract According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we reviewed all approved, investigational and experimental antiviral agents, which are safe in man, and identified 59 compounds that target at least three viral diseases. We tested 55 of these compounds against eight different RNA and DNA viruses. We found novel activities for dalbavancin against echovirus 1, ezetimibe against human immunodeficiency virus 1 and Zika virus, as well as azacitidine, cyclosporine, minocycline, oritavancin and ritonavir against Rift valley fever virus. Thus, the spectrum of antiviral activities of existing antiviral agents could be expanded towards other viral diseases.
has issue date	2018-06-30(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2018.04.016
bibo:pmid	29698664
has license	els-covid
sha1sum (hex)	3677d07462612a8eea30d7447559ca339f80f54b
schema:url	https://doi.org/10.1016/j.antiviral.2018.04.016
resource representing a document's title	Novel activities of safe-in-human broad-spectrum antiviral agents
has PubMed Central identifier	PMC7113852
has PubMed identifier	29698664
schema:publication	Antiviral Research
resource representing a document's body	covid:3677d07462612a8eea30d7447559ca339f80f54b#body_text
is schema:about of	named entity 'ezetimibe' named entity 'investigational' named entity 'SAFE' named entity 'BROAD' named entity 'NOVEL' named entity 'URGENT' named entity 'ROLE' named entity 'BETTER' named entity 'HERE' named entity 'COULD BE' named entity 'ACTIVITIES' named entity 'NOVEL' named entity 'VIRAL DISEASES' named entity 'THESE' named entity 'ACCORDING' named entity 'PROCESS' covid:arg/3677d07462612a8eea30d7447559ca339f80f54b named entity 'DALBAVANCIN' named entity 'REVIEWED' named entity 'VIRAL DISEASE' named entity 'EZETIMIBE' named entity 'DNA VIRUSES' named entity 'SPECTRUM' named entity 'ACTIVITIES' named entity 'HUMAN' named entity 'ANTIVIRAL AGENTS' named entity 'CONTROL' named entity 'PLAY' named entity 'APPROVED' named entity 'FOUND' named entity 'EXPERIMENTAL' named entity 'RNA' named entity 'ANTIVIRAL AGENTS' named entity 'ECHOVIRUS 1' named entity 'AZACITIDINE' named entity 'INVESTIGATIONAL' named entity 'EXPANDED ' named entity 'MAN' named entity 'NEED FOR' named entity 'CYCLOSPORINE' named entity 'TESTED' named entity 'TARGET' named entity 'ANTIVIRAL' named entity 'SPECTRUM' named entity 'RITONAVIR' named entity 'SAFE' named entity 'IDENTIFIED' named entity 'OTHER VIRAL DISEASES' named entity 'HUMAN IMMUNODEFICIENCY VIRUS 1'

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