About: Porcine epidemic diarrhea virus (PEDV) detection and antibody response in commercial growing pigs

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About: Porcine epidemic diarrhea virus (PEDV) detection and antibody response in commercial growing pigs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine epidemic diarrhea virus (PEDV) detection and antibody response in commercial growing pigs
Creator	Wang, Chong Gauger, Phillip Zhang, Jianqiang Baum, David Bjustrom-Kraft, Jordan Giménez-Lirola, Luis Lasley, Peter Main, Rodger Rotolo, Marisa Sun, Yaxuan Woodard, Katie Zimmerman, Jeffrey
topic	covid:3660a0a14f82558378797b8a86fb7d0854bd1ab4#this
Source	Medline; PMC
abstract	BACKGROUND: Longitudinal samples from two production sites were used to (1) describe the pattern of PEDV shedding (rRT-PCR) in individual rectal swabs, pen fecal samples, and pen oral fluids (OF); (2) describe the kinetics of PEDV antibody by ELISA (IgA, IgG) testing of pig serum and pen oral fluid samples; and (3) establish cutoffs and performance estimates for PEDV WV ELISAs (IgA, IgG). Site One was PEDV positive; Site Two was PEDV negative. On Site One, pen samples (feces and oral fluids) and pig samples (rectal swabs and sera) were collected both before and after the population was exposed to PEDV. RESULTS: On Site Two, pen oral fluid samples and individual pig serum samples were negative for both PEDV antibody and nucleic acid. On Site One, PEDV was detected by rRT-PCR at 6 days post exposure (DPE) in all sample types. The last rRT-PCR positives were detected in rectal swabs and oral fluids on 69 DPE. IgG and IgA were detected in oral fluids and serum samples by 13 DPE. Analysis of the PEDV serum IgG WV ELISA data showed that a sample-to-positive (S/P) cutoff of ≥ 0.80 provided a diagnostic sensitivity of 0.87 (95 % CI: 0.82, 0.91) and specificity of 0.99 (95 % CI: 0.98, 1.00). Serum IgG results declined slowly over the monitoring period, with 60 % of serum samples positive (S/P ≥ 0.80) at the final sampling on 111 DPE. Analysis of the PEDV oral fluid IgA WV ELISA found that a cutoff of S/P ≥ 0.80 provided a diagnostic sensitivity of 1.00 (95 % CI: 0.92, 1.00) and a diagnostic specificity of 1.00 (95 % CI: 0.99, 1.00). The oral fluid IgA response increased through 96 DPE and began to decline at the last sampling on 111 DPE. CONCLUSIONS: This study showed that oral fluid-based testing could provide an easy and “animal-friendly” approach to sample collection for nucleic acid and/or antibody-based surveillance of PEDV in swine populations.
has issue date	2016-06-10(xsd:dateTime)
bibo:doi	10.1186/s12917-016-0725-5
bibo:pmid	27287624
has license	cc-by
sha1sum (hex)	3660a0a14f82558378797b8a86fb7d0854bd1ab4
schema:url	https://doi.org/10.1186/s12917-016-0725-5
resource representing a document's title	Porcine epidemic diarrhea virus (PEDV) detection and antibody response in commercial growing pigs
has PubMed Central identifier	PMC4902975
has PubMed identifier	27287624
schema:publication	BMC Vet Res
resource representing a document's body	covid:3660a0a14f82558378797b8a86fb7d0854bd1ab4#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/3660a0a14f82558378797b8a86fb7d0854bd1ab4
is schema:about of	named entity 'individual' named entity 'response' named entity 'pig' named entity 'sampling' named entity 'One' named entity 'samples' named entity 'pen' named entity 'days' named entity 'specificity' named entity 'IgA' named entity 'samples' named entity 'GROWING PIGS' named entity 'POSITIVE' named entity 'FINAL' named entity 'DETECTED' named entity 'PATTERN' named entity 'RRT-PCR' named entity 'EXPOSED TO' named entity 'PEN' named entity '0.82' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'EXPOSURE' named entity 'RECTAL' named entity 'INCREASED' named entity 'FECAL' named entity 'SITE' named entity 'PERFORMANCE' named entity 'DAYS' named entity 'LONGITUDINAL' covid:arg/3660a0a14f82558378797b8a86fb7d0854bd1ab4 named entity 'USED' named entity 'ANALYSIS' named entity 'PRODUCTION' named entity 'DIAGNOSTIC SPECIFICITY' named entity 'RESPONSE' named entity 'NEGATIVE' named entity 'KINETICS' named entity 'ESTABLISH' named entity 'TESTING' named entity 'COMMERCIAL' named entity '28S' named entity 'SERA' named entity 'SAMPLE' named entity '0.92' named entity 'IGG' named entity '80%' named entity 'PIG' named entity 'SLOWLY' named entity 'ANTIBODY' named entity 'ANTIBODY RESPONSE' named entity 'PEDV' named entity 'SPECIFICITY' named entity 'SAMPLING' named entity 'INDIVIDUAL' named entity 'SAMPLES' named entity 'SHEDDING' named entity 'ORAL' named entity 'DPE' named entity 'PROVIDED' named entity 'POPULATION' named entity 'FOUND' named entity 'ORAL FLUID' named entity 'PCR' named entity 'DESCRIBE' named entity '0.99' named entity 'MONITORING' named entity 'ESTIMATES' named entity 'SITES'

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