About: MMP-8 Genotypes Influence the Inflammatory Response in Human Endotoxemia

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MMP-8 Genotypes Influence the Inflammatory Response in Human Endotoxemia
Creator	Fabry, Astrid Jilma, Bernd Mayr, Florian Murat Kaynar, A Rella, Judith
Source	PMC
abstract	Clinical studies have reported associations between MMP-8 genotypes and clinical outcomes without exploring underlying mechanisms. This study aims to understand the influence of the rs1940475 SNP on downstream chemokine and cytokine response in human endotoxemia. Rs1940475 was genotyped in 44 healthy Caucasian males, who were challenged with an intravenous bolus of 2 ng/kg lipopolysaccharide (LPS). Plasma levels of tumor necrosis factor (TNF), interleukin (IL)-6, IL-8, and macrophage inflammatory protein (MIP)-1α were measured at baseline and 2, 4, 6, and 24 h after LPS infusion with high-sensitivity enzyme immunoassays. Peak TNF levels at 2 h after LPS infusion were significantly higher in subjects with AA genotype compared to subjects with AG or GG genotypes (185 pg/mL [IQR, 154–234] vs. 94 pg/mL [IQR, 65–125] vs. 107 pg/mL [IQR, 80–241], respectively; p = 0.03 between groups). Peak IL-6 levels were trend-wise higher in subjects with AA genotype compared to those with AG or GG genotypes (566 pg/mL [IQR, 294–644] vs. 278 pg/mL [IQR, 184–539] and 329 pg/mL [IQR, 240–492], respectively; p = 0.15 between groups). In contrast, peak MIP-1α at 2 h was highest in GG genotype carriers compared to those with AG or AA genotypes (602 pg/mL [IQR, 449–727] vs. 389 pg/mL [IQR, 375–490] and 510 pg/mL [425–813], respectively; p < 0.03 between groups). AA genotype carriers had highest peak TNF and IL-6 levels after LPS challenge, whereas peak MIP-1α levels were highest in GG carriers. This indicates that the rs1940475 SNP modifies the host response to inflammatory stimuli, which may in part explain previously shown associations with clinical outcomes.
has issue date	2013-10-30(xsd:dateTime)
bibo:doi	10.1007/s10753-013-9758-0
bibo:pmid	24170307
has license	no-cc
sha1sum (hex)	363287146456208eeaffc0ec62e4c8c8b15fd6da
schema:url	https://doi.org/10.1007/s10753-013-9758-0
resource representing a document's title	MMP-8 Genotypes Influence the Inflammatory Response in Human Endotoxemia
has PubMed Central identifier	PMC7101851
has PubMed identifier	24170307
schema:publication	Inflammation
resource representing a document's body	covid:363287146456208eeaffc0ec62e4c8c8b15fd6da#body_text
is schema:about of	named entity 'genotype' named entity 'associations' named entity 'IQR' named entity 'interleukin' named entity 'mechanisms' named entity 'INTRAVENOUS BOLUS' named entity 'RESPONSE TO' named entity 'LEVELS' named entity 'IL-8' named entity 'INTERLEUKIN ' named entity 'CAUCASIAN' named entity 'PREVIOUSLY' named entity 'EXPLORING' named entity 'HAVE' named entity 'HEALTHY' named entity 'CYTOKINE ' named entity 'TUMOR NECROSIS FACTOR ' named entity 'IL-6 LEVELS' named entity 'GENOTYPE' named entity 'DOWNSTREAM' named entity 'higher' named entity 'infusion' named entity 'baseline' named entity 'SNP' named entity 'compared' named entity 'compared' named entity 'IQR' named entity 'cytokine' named entity 'influence' named entity 'genotypes' named entity 'TNF' named entity 'genotype' named entity 'pg/mL' named entity 'IL-8' named entity 'enzyme immunoassays' named entity 'interleukin (IL)-6' named entity 'pg/mL' named entity 'genotypes' named entity 'infusion' named entity 'MIP-1α' named entity 'MIP-1α' named entity 'genotype' named entity 'lipopolysaccharide' named entity 'inflammatory' named entity 'infusion' named entity 'Caucasian' named entity 'pg/mL' named entity 'genotype' named entity 'genotypes' named entity 'MMP-8' named entity 'inflammatory' named entity 'allele' named entity 'CAP' named entity 'MMP-8' named entity 'endotoxemia' named entity 'MMP-8' named entity 'MMP' named entity 'PMNs' named entity 'clinical outcomes' named entity 'allele' named entity 'organ damage' named entity 'MMP' named entity 'inflammatory' named entity 'LPS' named entity 'MIP' named entity 'acute lung injury' named entity 'allele' named entity 'laboratory testing' named entity 'MIP-1a' named entity 'mRNA' named entity 'MIP' named entity 'homozygous' named entity 'mice' named entity 'sample size' named entity 'MMP-8' named entity 'infusion' named entity 'allele'

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