About: Myocardial injury and COVID-19: Possible mechanisms

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Myocardial injury and COVID-19: Possible mechanisms
Creator	Amanullah, Aman Babapoor-Farrokhran, Savalan Bozorgnia, Behnam Gill, Deanna Rasekhi, Roozbeh Walker, Jackson Tarighati, Roozbeh
Source	Elsevier; Medline; PMC
abstract	Abstract Coronavirus Disease 2019 (COVID-19) has quickly progressed to a global health emergency. Respiratory illness is the major cause of morbidity and mortality in these patients with the disease spectrum ranging from asymptomatic subclinical infection, to severe pneumonia progressing to acute respiratory distress syndrome. There is growing evidence describing pathophysiological resemblance of SARS-CoV-2 infection with other coronavirus infections such as Severe Acute Respiratory Syndrome coronavirus and Middle East Respiratory Syndrome coronavirus (MERS-CoV). Angiotensin Converting Enzyme-2 receptors play a pivotal role in the pathogenesis of the virus. Disruption of this receptor leads to cardiomyopathy, cardiac dysfunction, and heart failure. Patients with cardiovascular disease are more likely to be infected with SARS-CoV-2 and they are more likely to develop severe symptoms. Hypertension, arrhythmia, cardiomyopathy and coronary heart disease are amongst major cardiovascular disease comorbidities seen in severe cases of COVID-19. There is growing literature exploring cardiac involvement in SARS-CoV-2. Myocardial injury is one of the important pathogenic features of COVID-19. As a surrogate for myocardial injury, multiple studies have shown increased cardiac biomarkers mainly cardiac troponins I and T in the infected patients especially those with severe disease. Myocarditis is depicted as another cause of morbidity amongst COVID-19 patients. The exact mechanisms of how SARS-CoV-2 can cause myocardial injury are not clearly understood. The proposed mechanisms of myocardial injury are direct damage to the cardiomyocytes, systemic inflammation, myocardial interstitial fibrosis, interferon mediated immune response, exaggerated cytokine response by Type 1 and 2 helper T cells, in addition to coronary plaque destabilization, and hypoxia.
has issue date	2020-04-28(xsd:dateTime)
bibo:doi	10.1016/j.lfs.2020.117723
bibo:pmid	32360126
has license	els-covid
sha1sum (hex)	35d28677e3b73accc05dbedf9a35fa836b976ca6
schema:url	https://doi.org/10.1016/j.lfs.2020.117723
resource representing a document's title	Myocardial injury and COVID-19: Possible mechanisms
has PubMed Central identifier	PMC7194533
has PubMed identifier	32360126
schema:publication	Life Sci
resource representing a document's body	covid:35d28677e3b73accc05dbedf9a35fa836b976ca6#body_text
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