About: Human Bocavirus Capsid Messenger RNA Detection in Children With Pneumonia

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About: Human Bocavirus Capsid Messenger RNA Detection in Children With Pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Bocavirus Capsid Messenger RNA Detection in Children With Pneumonia
Creator	Edwards, Kathryn Ampofo, Krow Stockmann, Chris Bramley, Anna Jain, Seema Hymas, Weston Blaschke, Anne Eilbeck, Karen Flygare, Steven Kennedy, Brett Schlaberg, Robert Yandell, Mark Simmon, Keith Tardif, Keith Arnold, Sandra Pavia, Andrew Williams, Derek Mccullers, Jon
Source	Medline; PMC
abstract	BACKGROUND: The role of human bocavirus (HBoV) in respiratory illness is uncertain. HBoV genomic DNA is frequently detected in both ill and healthy children. We hypothesized that spliced viral capsid messenger RNA (mRNA) produced during active replication might be a better marker for acute infection. METHODS: As part of the Etiology of Pneumonia in the Community (EPIC) study, children aged <18 years who were hospitalized with community-acquired pneumonia (CAP) and children asymptomatic at the time of elective outpatient surgery (controls) were enrolled. Nasopharyngeal/oropharyngeal specimens were tested for HBoV mRNA and genomic DNA by quantitative polymerase chain reaction. RESULTS: HBoV DNA was detected in 10.4% of 1295 patients with CAP and 7.5% of 721 controls (odds ratio [OR], 1.4 [95% confidence interval {CI}, 1.0–2.0]); HBoV mRNA was detected in 2.1% and 0.4%, respectively (OR, 5.1 [95% CI, 1.6–26]). When adjusted for age, enrollment month, and detection of other respiratory viruses, HBoV mRNA detection (adjusted OR, 7.6 [95% CI, 1.5–38.4]) but not DNA (adjusted OR, 1.2 [95% CI, .6–2.4]) was associated with CAP. Among children with no other pathogens detected, HBoV mRNA (OR, 9.6 [95% CI, 1.9–82]) was strongly associated with CAP. CONCLUSIONS: Detection of HBoV mRNA but not DNA was associated with CAP, supporting a pathogenic role for HBoV in CAP. HBoV mRNA could be a useful target for diagnostic testing.
has issue date	2017-07-22(xsd:dateTime)
bibo:doi	10.1093/infdis/jix352
bibo:pmid	28934425
has license	bronze-oa
sha1sum (hex)	354555332b24b37adcbc9b032b1357b8bebf9299
schema:url	https://doi.org/10.1093/infdis/jix352
resource representing a document's title	Human Bocavirus Capsid Messenger RNA Detection in Children With Pneumonia
has PubMed Central identifier	PMC5853397
has PubMed identifier	28934425
schema:publication	The Journal of Infectious Diseases
resource representing a document's body	covid:354555332b24b37adcbc9b032b1357b8bebf9299#body_text
is schema:about of	named entity 'messenger RNA' named entity 'Capsid' named entity 'JOURNAL ' named entity 'MIGHT BE' named entity 'SPLICED' named entity 'CHILDREN' named entity 'UNCERTAIN' named entity 'INFECTIOUS DISEASES' named entity 'HUMAN BOCAVIRUS' named entity 'PNEUMONIA' named entity 'MESSENGER RNA' named entity 'CAPSID' named entity 'DETECTION' named entity 'FREQUENTLY' named entity 'BETTER' named entity 'CHILDREN' named entity 'GENOMIC DNA' named entity 'MESSENGER RNA' named entity 'ACUTE INFECTION' named entity 'ACTIVE' named entity 'REPLICATION' named entity 'MARKER' named entity 'DETECTED' named entity 'RESPIRATORY ILLNESS' named entity 'HEALTHY' named entity 'BACKGROUND' named entity 'VIRAL CAPSID' named entity 'ROLE' named entity 'ILL' named entity 'HUMAN BOCAVIRUS' covid:arg/354555332b24b37adcbc9b032b1357b8bebf9299 named entity 'replication' named entity 'human bocavirus' named entity 'genomic DNA' named entity 'mRNA' named entity 'human bocavirus' named entity 'HBoV' named entity 'Human Bocavirus' named entity 'Journal of Infectious Diseases' named entity 'splice variant' named entity 'viral load' named entity 'metapneumovirus' named entity 'respiratory disease' named entity 'CAP' named entity 'mRNA transcripts' named entity 'capsid' named entity 'CAP' named entity 'diarrhea' named entity 'interquartile range' named entity '95% CI' named entity 'PCR' named entity 'respiratory syncytial virus' named entity 'epidemiologic studies' named entity 'Human bocavirus' named entity 'CAP' named entity 'capsid' named entity 'chills' named entity 'control groups' named entity 'thermocycler' named entity 'acute infection' named entity 'collection of blood' named entity 'analysis of variance' named entity 'Qiagen' named entity 'viruses'

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