About: Structural basis for the function of anti-idiotypic antibody in immune memory

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About: Structural basis for the function of anti-idiotypic antibody in immune memory Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural basis for the function of anti-idiotypic antibody in immune memory
Creator	Chandra, Nagasuma Chatterjee, Jhinuk Shaila, Nayak, R Vani, J
topic	covid:3534d9445c578cdc048c8b7f7ace2384f58636ea#this
Source	Elsevier; Medline; PMC
abstract	Abstract We had earlier proposed a hypothesis to explain the mechanism of perpetuation of immunological memory based on the operation of idiotypic network in the complete absence of antigen. Experimental evidences were provided for memory maintenance through anti-idiotypic antibody (Ab2) carrying the internal image of the antigen. In the present work, we describe a structural basis for such memory perpetuation by molecular modeling and structural analysis studies. A three-dimensional model of Ab2 was generated and the structure of the antigenic site on the hemagglutinin protein H of Rinderpest virus was modeled using the structural template of hemagglutinin protein of Measles virus. Our results show that a large portion of heavy chain containing the CDR regions of Ab2 resembles the domain of the hemagglutinin housing the epitope regions. The similarity demonstrates that an internal image of the H antigen is formed in Ab2, which provides a structural basis for functional mimicry demonstrated earlier. This work brings out the importance of the structural similarity between a domain of hemagglutinin protein to that of its corresponding Ab2. It provides evidence that Ab2 is indeed capable of functioning as surrogate antigen and provides support to earlier proposed relay hypothesis which has provided a mechanism for the maintenance of immunological memory.
has issue date	2009-03-31(xsd:dateTime)
bibo:doi	10.1016/j.molimm.2008.11.019
bibo:pmid	19157554
has license	els-covid
sha1sum (hex)	3534d9445c578cdc048c8b7f7ace2384f58636ea
schema:url	https://doi.org/10.1016/j.molimm.2008.11.019
resource representing a document's title	Structural basis for the function of anti-idiotypic antibody in immune memory
has PubMed Central identifier	PMC7126318
has PubMed identifier	19157554
schema:publication	Molecular Immunology
resource representing a document's body	covid:3534d9445c578cdc048c8b7f7ace2384f58636ea#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/3534d9445c578cdc048c8b7f7ace2384f58636ea
is schema:about of	named entity 'MECHANISM' named entity 'HEMAGGLUTININ' named entity 'DEMONSTRATED' named entity 'H ANTIGEN' named entity 'BASED' named entity 'CONTAINING' named entity 'EVIDENCE' named entity 'ABSENCE OF' named entity 'FUNCTIONAL' named entity 'PROVIDED' named entity 'MEASLES VIRUS' named entity 'USING' named entity 'SITE' named entity 'WORK' named entity 'THREE-DIMENSIONAL' named entity 'CAPABLE' named entity 'COMPLETE' named entity 'SURROGATE' named entity 'PROPOSED' named entity 'BASIS' named entity 'NETWORK' named entity 'MAINTENANCE' named entity 'PORTION' named entity 'LARGE' named entity 'CDR' named entity 'STRUCTURAL ANALYSIS' named entity 'MIMICRY' named entity 'STRUCTURAL' named entity 'FUNCTION' named entity 'IMMUNE' named entity 'ANTIBODY' named entity 'MEMORY' named entity 'EARLIER' named entity 'PROTEIN ' named entity 'IMMUNOLOGICAL MEMORY' named entity 'CARRYING' named entity 'MOLECULAR MODELING' named entity 'ITS' named entity 'STRUCTURAL' named entity 'BASIS' named entity 'SUPPORT' named entity 'DESCRIBE' named entity 'RESULTS' named entity 'PROVIDES' named entity 'FUNCTIONING' named entity 'HOUSING' named entity 'HYPOTHESIS' named entity 'IMAGE' named entity 'INTERNAL' named entity 'GENERATED' named entity 'PROTEIN H' named entity 'EPITOPE' named entity 'PRESENT' named entity 'MEMORY' named entity 'REGIONS' named entity 'RELAY' named entity 'STRUCTURE' named entity 'HEAVY CHAIN' named entity 'FORMED' named entity 'ANTIGEN' named entity 'EXPERIMENTAL' named entity 'TEMPLATE' named entity 'DOMAIN' named entity 'OUR' named entity 'STUDIES' named entity 'MODEL OF' named entity 'TO EXPLAIN' named entity 'MODELED' named entity 'OPERATION' named entity 'RINDERPEST VIRUS' named entity 'ANTIBODY' named entity 'SIMILARITY' covid:arg/3534d9445c578cdc048c8b7f7ace2384f58636ea named entity 'protein' named entity 'anti-idiotypic'

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