About: Lactic acid bacteria efficiently protect human and animal intestinal epithelial and immune cells from enteric virus infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lactic acid bacteria efficiently protect human and animal intestinal epithelial and immune cells from enteric virus infection
Creator	Cencic, Avrelija Chingwaru, Walter Gradisnik, Lidija Tsakalidou, Effie Maragkoudakis, Petros
Source	Elsevier; Medline; PMC
abstract	Abstract This study aimed to examine the potential antiviral activity of lactic acid bacteria (LAB) using animal and human intestinal and macrophage cell line models of non tumor origin. To this end, LAB strains selected on the basis of previous in vitro trials were co-incubated with cell line monolayers, which were subsequently challenged with rotavirus (RV) and transmissible gastroenteritis virus (TGEV). In order to elucidate the possible mechanism responsible for the antiviral activity, the induction of reactive oxygen species (ROS) release as well as the attachment ability of LAB on the cell lines was investigated. Various strains were found to exhibit moderate to complete monolayer protection against viral RV or TGEV disruption. Highest protection effects were recorded with the known probiotics Lactobacillus rhamnosus GG and Lactobacillus casei Shirota against both RV and TGEV, while notable antiviral activity was also attributed to Enterococcus faecium PCK38, Lactobacillus fermentum ACA-DC179, Lactobacillus pentosus PCA227 and Lactobacillus plantarum PCA236 and PCS22, depending on the cell line and virus combination used. A variable increase (of up to 50%) on the release of NO− and H2O2 (ROS) was obtained when LAB strains were co-incubated with the cell lines, but the results were found to be LAB strain and cell line specific, apart from a small number of strains which were able to induce strong ROS release in more than one cell line. In contrast, the ability of the examined LAB strains to attach to the cell line monolayers was LAB strain but not cell line specific. Highest attachment ability was observed with L. plantarum ACA-DC 146, L. paracasei subsp. tolerans ACA-DC 4037 and E. faecium PCD71. Clear indications on the nature of the antiviral effect were evident only in the case of the L. casei Shirota against TGEV and with L. plantarum PCA236 againt both RV and TGEV. In the rest of the cases, each interaction was LAB-cell line–virus specific, barring general conclusions. However, it is probable that more than one mechanism is involved in the antiviral effect described here. Further investigations are required to elucidate the underlying mode of action and to develop a cell line model as a system for selection of probiotic strains suited for farm animal applications.
has issue date	2010-07-31(xsd:dateTime)
bibo:doi	10.1016/j.ijfoodmicro.2009.12.024
bibo:pmid	20106541
has license	els-covid
sha1sum (hex)	353253dbab75f1dbaa3a55de166b3c5b97bbabf0
schema:url	https://doi.org/10.1016/j.ijfoodmicro.2009.12.024
resource representing a document's title	Lactic acid bacteria efficiently protect human and animal intestinal epithelial and immune cells from enteric virus infection
has PubMed Central identifier	PMC7114074
has PubMed identifier	20106541
schema:publication	International Journal of Food Microbiology
resource representing a document's body	covid:353253dbab75f1dbaa3a55de166b3c5b97bbabf0#body_text
is schema:about of	named entity 'INTESTINAL' named entity 'CELL LINES' named entity 'VIRUS INFECTION' named entity 'ANIMAL' covid:arg/353253dbab75f1dbaa3a55de166b3c5b97bbabf0 named entity 'EPITHELIAL' named entity 'ENTERIC' named entity 'BACTERIA ' named entity 'R T' named entity 'T A' named entity 'HUMAN' named entity 'IMMUNE CELLS' named entity 'LACTIC ACID BACTERIA' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'REACTIVE OXYGEN SPECIES' named entity 'ATTACHMENT' named entity 'KEYWORDS' named entity 'S T' named entity 'ROTAVIRUS' named entity 'PROBIOTIC' named entity 'Rotavirus' named entity 'bacteria' named entity 'Transmissible gastroenteritis virus' named entity 'Rotavirus' named entity 'virus' named entity 'intestinal epithelial' named entity 'probiotic' named entity 'cell lines' named entity 'macrophage' named entity 'farm animals' named entity 'CLAB' named entity 'E. faecium' named entity 'probiotic' named entity 'intestinal lumen' named entity 'DMEM' named entity 'Lievin' named entity 'cell line' named entity 'macrophage' named entity 'antiviral' named entity 'glycerol' named entity 'inflammatory responses' named entity 'epithelial cell' named entity 'intestinal epithelial cell' named entity 'serial dilution' named entity 'E. faecium' named entity 'antiviral' named entity 'ROS' named entity 'macrophage' named entity 'non-attached' named entity 'secretion' named entity 'tumor cells' named entity 'TGEV' named entity 'Agricultural University of Athens' named entity 'viruses' named entity 'bacteria' named entity 'cell line' named entity 'research project' named entity 'farm animal welfare' named entity 'viruses' named entity 'vesicular stomatitis virus' named entity 'CLAB' named entity 'L. plantarum' named entity 'Danisco' named entity 'CLAB' named entity 'probiotic' named entity 'porcine' named entity 'GIE' named entity 'ruminant' named entity 'farm animals' named entity 'probiotic' named entity 'TGEV' named entity 'cell line' named entity 'epithelial cell' named entity 'reactive oxygen species' named entity 'cell lines' named entity 'holistic approach' named entity 'Keyaerts'

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