About: OASes and STING: Adaptive Evolution in Concert

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	OASes and STING: Adaptive Evolution in Concert
Creator	Cagliani, Rachele Clerici, Mario Forni, Diego Pontremoli, Chiara Pozzoli, Uberto Sironi, Manuela Mozzi, Alessandra Bresolin, Nereo
Source	Medline; PMC
abstract	OAS (2′–5′-oligoadenylate synthases) proteins and cyclic GMP–AMP synthase (cGAS, gene symbol: MB21D1) patrol the cytoplasm for the presence of foreign nucleic acids. Upon binding to double-stranded RNA or double-stranded DNA, OAS proteins and cGAS produce nucleotide second messengers to activate RNase L and STING (stimulator of interferon genes, gene symbol: TMEM173), respectively; this leads to the initiation of antiviral responses. We analyzed the evolutionary history of the MB21D1–TMEM173 and OAS–RNASEL axes in primates and bats and found evidence of widespread positive selection in both orders. In TMEM173, residue 230, a major determinant of response to natural ligands and to mimetic drugs (e.g., DMXAA), was positively selected in Primates and Chiroptera. In both orders, selection also targeted an α-helix/loop element in RNase L that modulates the enzyme preference for single-stranded RNA versus stem loops. Analysis of positively selected sites in OAS1, OAS2, and MB21D1 revealed parallel evolution, with the corresponding residues being selected in different genes. As this cannot result from gene conversion, these data suggest that selective pressure acting on OAS and MB21D1 genes is related to nucleic acid recognition and to the specific mechanism of enzyme activation, which requires a conformational change. Finally, a population genetics-phylogenetics analysis in humans, chimpanzees, and gorillas detected several positively selected sites in most genes. Data herein shed light into species-specific differences in infection susceptibility and in response to synthetic compounds, with relevance for the design of synthetic compounds as vaccine adjuvants.
has issue date	2015-03-09(xsd:dateTime)
bibo:doi	10.1093/gbe/evv046
bibo:pmid	25752600
has license	cc-by
sha1sum (hex)	34f0507e2d36312bb0a90c6c9a66acd14d9154c3
schema:url	https://doi.org/10.1093/gbe/evv046
resource representing a document's title	OASes and STING: Adaptive Evolution in Concert
has PubMed Central identifier	PMC4419793
has PubMed identifier	25752600
schema:publication	Genome Biol Evol
resource representing a document's body	covid:34f0507e2d36312bb0a90c6c9a66acd14d9154c3#body_text
is schema:about of	named entity 'history' named entity 'susceptibility' named entity 'TMEM173' named entity 'OAS' named entity 'single-stranded' named entity 'Chiroptera' named entity 'selective pressure' named entity 'response' named entity 'bats' named entity 'parallel evolution' covid:arg/34f0507e2d36312bb0a90c6c9a66acd14d9154c3 named entity 'preference' named entity 'drugs' named entity 'nucleic acids' named entity 'synthases' named entity 'Primates' named entity 'positively selected' named entity 'stem loops' named entity 'adjuvants' named entity 'targeted' named entity 'acting' named entity 'evidence' named entity 'RNA' named entity 'initiation' named entity 'genes' named entity 'single-stranded RNA' named entity 'ligands' named entity 'double-stranded RNA' named entity 'positively selected' named entity 'evolutionary history' named entity 'nucleic acid' named entity 'enzyme activation' named entity 'phylogenetics' named entity 'antiviral' named entity 'TMEM173' named entity 'TMEM173' named entity 'positive selection' named entity 'Chiroptera' named entity 'cGAS' named entity 'TMEM173' named entity 'adaptive evolution' named entity 'Myotis davidii' named entity 'cGAS' named entity 'paralogs' named entity 'leucine' named entity 'HBV' named entity 'gene conversion' named entity 'positively charged' named entity 'M2a' named entity 'immune response' named entity 'gene' named entity 'OAS1' named entity 'population genetics' named entity 'Deletions' named entity 'OAS1' named entity 'N-terminus' named entity 'phylogeny' named entity 'random effects' named entity 'OAS1' named entity 'DNA and RNA' named entity 'MAVS' named entity 'viral protein' named entity 'statistical support' named entity 'ER retention' named entity 'codon' named entity 'genomic DNA' named entity 'innate immunity' named entity 'tree shrew' named entity 'PDB' named entity 'Chiroptera' named entity 'PRRs' named entity 'STING' named entity 'cGAS' named entity 'evolution'

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