About: Low pathogenic avian influenza virus infection increases the staining intensity of KUL01+ cells including macrophages yet decrease of the staining intensity of KUL01+ cells using clodronate liposomes did not affect the viral genome loads in chickens

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About: Low pathogenic avian influenza virus infection increases the staining intensity of KUL01+ cells including macrophages yet decrease of the staining intensity of KUL01+ cells using clodronate liposomes did not affect the viral genome loads in chickens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Low pathogenic avian influenza virus infection increases the staining intensity of KUL01+ cells including macrophages yet decrease of the staining intensity of KUL01+ cells using clodronate liposomes did not affect the viral genome loads in chickens
Creator	Ehiremen, Godsent Nagy, Eva Faizal, Mohamed Sarjoon Abdul-Cader, Mohamed
Source	Elsevier; Medline; PMC
abstract	The effect of depletion of macrophages using clodronate liposomes as well as macrophage response following viral infections have been studied in various mouse-virus infection models, but they have not been extensively studied in chickens relevant to virus infections. When we infected day 6 chickens with H4N6 low pathogenic avian influenza virus (LPAIV), we observed that H4N6 LPAIV infection increased the staining intensity of KUL01+ cells in trachea, lungs and duodenum of chickens at 3 days post-infection. Then, we used clodronate liposomes intra-abdominally in 5 day-old chickens and found significant reduction of staining intensity of KUL01+ cells in trachea and duodenum but not in lungs at 4 days post-treatment. When we infected the clodronate liposome and PBS liposome treated chickens with H4N6 LPAIV intra-nasally at day 6, we found no effect on H4N6 LPAIV genome loads in trachea, lungs and duodenum of chickens. This study indicates that although KUL01+ cell intensity are increased in respiratory and gastrointestinal tissues in chickens following H4N6 LPAIV infection, the decrease of KUL01+ cell intensity using clodronate liposomes did not change the H4N6 LPAIV genome loads in any of the examined tissues suggesting that KUL01+ cells may not be critical during H4N6 LPAIV infection in chicken.
has issue date	2018-02-23(xsd:dateTime)
bibo:doi	10.1016/j.vetimm.2018.02.009
bibo:pmid	29571516
has license	no-cc
sha1sum (hex)	34e8d5c4865aaa4101c3bcf44c01bc483046026a
schema:url	https://doi.org/10.1016/j.vetimm.2018.02.009
resource representing a document's title	Low pathogenic avian influenza virus infection increases the staining intensity of KUL01+ cells including macrophages yet decrease of the staining intensity of KUL01+ cells using clodronate liposomes did not affect the viral genome loads in chickens
has PubMed Central identifier	PMC7112785
has PubMed identifier	29571516
schema:publication	Vet Immunol Immunopathol
resource representing a document's body	covid:34e8d5c4865aaa4101c3bcf44c01bc483046026a#body_text
is schema:about of	named entity 'PATHOGENIC' named entity 'macrophages' named entity 'staining' named entity 'USING' named entity 'DECREASE' named entity 'AVIAN INFLUENZA VIRUS' named entity 'CHICKENS' named entity 'CELLS' named entity 'DID' named entity 'LIPOSOMES' named entity 'MACROPHAGES' named entity 'CLODRONATE' named entity 'INCLUDING' named entity 'VIRAL GENOME' named entity 'INCREASES' named entity 'LOW' named entity 'VIRUS INFECTION' named entity 'STAINING INTENSITY' named entity 'AFFECT' named entity 'infection' named entity 'macrophages' named entity 'staining' named entity 'macrophages' named entity 'infection' named entity 'DAPI' named entity 'trachea' named entity 'Canadian Food Inspection Agency' named entity 'infection' named entity 'microbes' named entity 'lung' named entity 'staining' named entity 'CFIA' named entity 'macrophages' named entity 'macrophages' named entity 'duodenum' named entity 'clodronate' named entity 'H3N2' named entity 'duodenum' named entity 'liposomes' named entity 'chicken' named entity 'avian influenza virus' named entity 'duodenum' named entity 'clodronate' named entity 'infection' named entity 'macrophages' named entity 'Marek's disease' named entity 'IL-1β' named entity 'duodenum' named entity 'avian influenza virus' named entity 'Liposome' named entity 'duodenum' named entity 'incubation' named entity 'macrophage' named entity 'duodenum' named entity 'viral replication' named entity 'Bethesda, Maryland' named entity 'real-time PCR' named entity 'clodronate' named entity 'staining' named entity 'genome' named entity 'liposomes' named entity 'HRIC' named entity 'macrophages' named entity 'lungs' named entity 'liposomes' named entity 'avian influenza virus' named entity 'trachea' named entity 'phagocytosed' named entity 'genome' named entity 'adenovirus' named entity 'virus infections' named entity 'viral infections' named entity 'macrophages, monocytes' named entity 'laryngotracheitis' named entity 'nitric oxide' named entity 'infectious bronchitis virus' named entity 'chicken' named entity 'trachea'

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