About: Inflammatory monocytes and the pathogenesis of viral encephalitis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Inflammatory monocytes and the pathogenesis of viral encephalitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inflammatory monocytes and the pathogenesis of viral encephalitis
Creator	Deffrasnes, Celine King, Nicholas Terry, Rachael Campbell, Iain Getts, Daniel Van Vreden, Caryn
Source	Medline; PMC
abstract	Monocytes are a heterogeneous population of bone marrow-derived cells that are recruited to sites of infection and inflammation in many models of human diseases, including those of the central nervous system (CNS). Ly6C(hi)/CCR2(hi) inflammatory monocytes have been identified as the circulating precursors of brain macrophages, dendritic cells and arguably microglia in experimental autoimmune encephalomyelitis; Alzheimer’s disease; stroke; and more recently in CNS infection caused by Herpes simplex virus, murine hepatitis virus, Theiler’s murine encephalomyelitis virus, Japanese encephalitis virus and West Nile virus. The precise differentiation pathways and functions of inflammatory monocyte-derived populations in the inflamed CNS remains a contentious issue, especially in regard to the existence of monocyte-derived microglia. Furthermore, the contributions of monocyte-derived subsets to viral clearance and immunopathology are not well-defined. Thus, understanding the pathways through which inflammatory monocytes migrate to the brain and their functional capacity within the CNS is critical to inform future therapeutic strategies. This review discusses some of the key aspects of inflammatory monocyte trafficking to the brain and addresses the role of these cells in viral encephalitis.
has issue date	2012-12-17(xsd:dateTime)
bibo:doi	10.1186/1742-2094-9-270
bibo:pmid	23244217
has license	cc-by
sha1sum (hex)	34e4b49c46c5462089f516983eeb19a6aff69d01
schema:url	https://doi.org/10.1186/1742-2094-9-270
resource representing a document's title	Inflammatory monocytes and the pathogenesis of viral encephalitis
has PubMed Central identifier	PMC3560265
has PubMed identifier	23244217
schema:publication	J Neuroinflammation
resource representing a document's body	covid:34e4b49c46c5462089f516983eeb19a6aff69d01#body_text
is schema:about of	named entity 'regard' named entity 'immunopathology' named entity 'differentiation' named entity 'disease' named entity 'heterogeneous' named entity 'STROKE' named entity 'ADDRESSES' named entity 'IMMUNOPATHOLOGY' named entity 'MONOCYTE' named entity 'PRECISE' named entity 'RECENTLY' named entity 'POPULATION' named entity 'CELLS' named entity 'FUNCTIONS' named entity 'MODELS' named entity 'FUTURE' named entity 'ISSUE' named entity '27S' named entity 'JAPANESE ENCEPHALITIS VIRUS' named entity 'STRATEGIES' named entity 'WELL-DEFINED' named entity 'THESE' named entity 'ROLE' named entity 'PATHWAYS' named entity 'MIGRATE' named entity 'SITES' named entity 'VIRAL CLEARANCE' named entity 'BRAIN' named entity 'WEST NILE VIRUS' named entity 'EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS' named entity 'VIRAL ENCEPHALITIS' named entity 'CAUSED BY' named entity 'KEY' named entity 'IDENTIFIED' named entity 'BONE MARROW' named entity 'UNDERSTANDING' named entity 'REGARD' named entity 'INFLAMMATION' named entity 'CIRCULATING' named entity 'MURINE HEPATITIS VIRUS' named entity 'INCLUDING' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'HERPES SIMPLEX VIRUS' named entity 'THERAPEUTIC' named entity 'VIRAL ENCEPHALITIS' named entity 'MONOCYTES' named entity 'CCR2' named entity 'PATHOGENESIS' named entity 'INFLAMMATORY' named entity 'MACROPHAGES' named entity 'CNS' named entity 'MICROGLIA' named entity 'DIFFERENTIATION' named entity 'INFLAMMATORY MONOCYTE' named entity 'DISEASE' named entity 'DERIVED' named entity 'DENDRITIC CELLS' named entity 'CNS INFECTION' named entity 'LY6C' named entity 'HAVE' named entity 'TRAFFICKING' named entity 'THEIR' named entity 'INFLAMED' named entity 'INFECTION' named entity 'CRITICAL' named entity 'ALZHEIMER' named entity 'INFLAMMATORY' named entity 'MURINE ENCEPHALOMYELITIS VIRUS' named entity 'PRECURSORS' named entity 'FUNCTIONAL CAPACITY' named entity 'MONOCYTES' named entity 'TO INFORM' named entity 'NOT WELL' named entity 'HUMAN DISEASES' named entity 'REVIEW' named entity 'HETEROGENEOUS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software