About: Suppressed T cell-mediated immunity in patients with COVID-19: a clinical retrospective study in Wuhan, China

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About: Suppressed T cell-mediated immunity in patients with COVID-19: a clinical retrospective study in Wuhan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Suppressed T cell-mediated immunity in patients with COVID-19: a clinical retrospective study in Wuhan, China
Creator	Miao, Qing Xu, Bo Cong, He△ Fan, Cun-Yu Fan△, Cun-Yu He, Cong Miao☆, Qing Other, ; Wang, An-Lu Wang☆, An-Lu Xia, Wen-Guang Xia△, Wen-Guang Xu△, Bo Yu, Yi-Han Yu△, Yi-Han Zhang, Ji-Xian Zhang△, Ji-Xian Zou, Yi-Long Zou△, Yi-Long
source	Elsevier; Medline; PMC
abstract	Abstract Importance An ongoing outbreak of COVID-19 has exhibited significant threats around the world. We found a significant decrease of T lymphocyte subsets and an increase of inflammatory cytokines of hospitalized patients with COVID-19 in clinical practice. Methods We conducted a retrospective, single-center observational study of in-hospital adult patients with confirmed COVID-19 in Hubei Provincial Hospital of traditional Chinese and Western medicine (Wuhan, China) by Mar 1, 2020. Demographic, clinical, laboratory information, especially T lymphocyte subsets and inflammatory cytokines were reported. For patients who died or discharge from hospital, the associations of T lymphocyte subsets on admission were evaluated by univariate logistic regression with odds ratios (ORs) and 95% confidence intervals (CIs), warning values to predict in-hospital death were assessed by Receiver Operator Characteristic (ROC) curves. Results A total of 187 patients were enrolled in our study from Dec 26, 2019 to Mar 1, 2020, of whom 145 were survivors (discharge= 117) or non-survivors (in-hospital death=28). All patients exhibited a significant drop of T lymphocyte subsets counts with remarkably increasing concentrations of SAA, CRP, IL-6, and IL-10 compared to normal values. The median concentrations of SAA and CRP in critically-ill patients were nearly 4- and 10-fold than those of mild-ill patients, respectively. As the severity of COVID-19 getting worse, the counts of T lymphocyte drop lower.28 patients died in hospital, the median lymphocyte, CD3+ T-cell, CD4+ T-cell, CD8+ T-cell and B-cell were significantly lower than other patients. Lower counts (/uL) of T lymphocyte subsets lymphocyte (<500), CD3+T-cell (<200), CD4+ T-cell (<100), CD8+ T-cell (<100) and B-cell (<50) were associated with higher risks of in-hospital death of CIVID-19. The warning values to predict in-hospital death of lymphocyte, CD3+ T-cell, CD4+ T-cell, CD8+ T-cell, and B-cell were 559, 235, 104, 85 and 82, respectively. Conclusion We find a significant decrease of T lymphocyte subset is positively correlated with in-hospital death and severity of illness. The decreased levels of T lymphocyte subsets reported in our study were similar with SARS but not common among other virus infection, which may be possible biomarkers for early diagnosis of COVID-19. Our findings may shed light on early warning of high risks of mortality and help early intervention and treatment of COVID-19.
has issue date	2020-04-18(xsd:dateTime)
bibo:doi	10.1016/j.jinf.2020.04.012
bibo:pmid	32315725
has license	els-covid
sha1sum (hex)	34bb7c0b70a65346092067f7c0983de1f92ef5e2
schema:url	https://doi.org/10.1016/j.jinf.2020.04.012
resource representing a document's title	Suppressed T cell-mediated immunity in patients with COVID-19: a clinical retrospective study in Wuhan, China
has PubMed Central identifier	PMC7166040
has PubMed identifier	32315725
schema:publication	J Infect
resource representing a document's body	covid:34bb7c0b70a65346092067f7c0983de1f92ef5e2#body_text
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