About: Antiviral activities of ISG20 in positive-strand RNA virus infections

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Antiviral activities of ISG20 in positive-strand RNA virus infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral activities of ISG20 in positive-strand RNA virus infections
Creator	Rijnbrand, Rene Holbrook, Michael Guo, Ju-Tao Wei, Lai Li, Kui Zhou, Zhi Wang, Jie Dong, Qingming Wang, Nan Liang, Yuqiong Lemon, Stanley Nichols, Joan Woodson, Sara
Source	Elsevier; Medline; PMC
abstract	Abstract ISG20 is an interferon-inducible 3′–5′ exonuclease that inhibits replication of several human and animal RNA viruses. However, the specificities of ISG20's antiviral action remain poorly defined. Here we determine the impact of ectopic expression of ISG20 on replication of several positive-strand RNA viruses from distinct viral families. ISG20 inhibited infections by cell culture-derived hepatitis C virus (HCV) and a pestivirus, bovine viral diarrhea virus and a picornavirus, hepatitis A virus. Moreover, ISG20 demonstrated cell-type specific antiviral activity against yellow fever virus, a classical flavivirus. Overexpression of ISG20, however, did not inhibit propagation of severe acute respiratory syndrome coronavirus, a highly-pathogenic human coronavirus in Huh7.5 cells. The antiviral effects of ISG20 were all dependent on its exonuclease activity. The closely related cellular exonucleases, ISG20L1 and ISG20L2, did not inhibit HCV replication. Together, these data may help better understand the antiviral specificity and action of ISG20.
has issue date	2011-01-20(xsd:dateTime)
bibo:doi	10.1016/j.virol.2010.10.008
bibo:pmid	21036379
has license	els-covid
sha1sum (hex)	3489ec2ad98743262cdd5d6735b3a3f13878cc62
schema:url	https://doi.org/10.1016/j.virol.2010.10.008
resource representing a document's title	Antiviral activities of ISG20 in positive-strand RNA virus infections
has PubMed Central identifier	PMC3018280
has PubMed identifier	21036379
schema:publication	Virology
resource representing a document's body	covid:3489ec2ad98743262cdd5d6735b3a3f13878cc62#body_text
is schema:about of	named entity 'RNA virus' named entity 'INTERFERON ' named entity 'BOVINE VIRAL DIARRHEA VIRUS' named entity 'INNATE IMMUNITY' named entity 'ANTIVIRAL' named entity 'YELLOW FEVER VIRUS' named entity 'ISG20L1' named entity 'ISG20' named entity 'ACTIVITIES' named entity 'RNA VIRUS INFECTIONS' named entity 'ANTIVIRAL' named entity 'ISG20L2' named entity 'KEYWORDS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'HEPATITIS A VIRUS' named entity 'ISG20' named entity 'VIRUS HEPATITIS' named entity 'HEPATITIS C VIRUS' named entity 'POSITIVE-STRAND RNA VIRUS' covid:arg/3489ec2ad98743262cdd5d6735b3a3f13878cc62 named entity 'virus' named entity 'Hepatitis C virus' named entity 'ISG20' named entity 'Yellow fever virus' named entity 'ISG20' named entity 'ISG20' named entity 'ISG20' named entity 'IFN' named entity 'virus' named entity 'luciferase' named entity 'hepatitis viruses' named entity 'viral entry' named entity 'titrated' named entity 'coding sequences' named entity 'encephalomyocarditis virus' named entity 'YFV' named entity 'mAb' named entity 'ISG20' named entity 'p53' named entity 'mRNA' named entity 'TRIzol' named entity 'SARS-CoV' named entity 'HEK293 cells' named entity 'HCV' named entity 'Huh7' named entity 'HCV' named entity '7.5' named entity 'resistance gene' named entity '7.5' named entity '7.5' named entity 'ISG56' named entity 'transfection' named entity 'mutation' named entity 'Huh7' named entity 'gene' named entity 'ISG20' named entity 'hepatoma' named entity 'EMCV' named entity 'Arboviruses' named entity 'actin' named entity 'HCV' named entity 'antiviral' named entity 'cell lysis' named entity 'N-terminus' named entity 'HEK293 cells' named entity '7.5' named entity 'RNA replication' named entity 'PCR analysis' named entity 'cell types'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software