About: Systemic varicella-zoster virus infection in two critically ill patients in an intensive care unit

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Systemic varicella-zoster virus infection in two critically ill patients in an intensive care unit
Creator	Hagiya, Hideharu Kimura, Maya Miyamoto, Toru Otsuka, Fumio
source	PMC
abstract	Varicella-zoster virus (VZV) usually causes localized zoster in adults. However, in immunocompromised patients, it can cause systemic infection accompanied by complications such as pneumonia, encephalitis, and hepatitis. Although most of critically ill patients in intensive care unit (ICU) are immunologically compromised, they are usually not considered to be at risk for systemic VZV infection. We report two cases of systemic VZV infection occurring in critically ill patients in an ICU. One patient was a 69-year-old man with Streptococcus pneumoniae-induced purpurafulminans, and the other was a 75-year-old woman with severe acute pancreatitis. During the clinical course in the ICU, characteristic vesicles with umbilical fossa appeared diffusely and bilaterally on their face, trunk, and extremities. VZV-specific IgG levels were confirmed to be elevated compared to that of the pre-onset, and a diagnosis of recurrent VZV infection was made in both patients. The patients were treated at the same ICU but did not coincide with each other; therefore a cross-infection was unlikely. They were treated with intravenous acyclovir, but the latter patient eventually died of respiratory failure. VZV infection can cause a number of serious complications, and can lead to death in some patients. Early detection and proper treatment are needed to prevent the infection from spreading out and save the patients. It might be necessary to consider antiviral prophylaxis against VZV infection for a part of critically ill patients in ICU, although the effectiveness of this approach is yet to be established.
has issue date	2013-07-08(xsd:dateTime)
bibo:doi	10.1186/1743-422x-10-225
bibo:pmid	23829348
has license	cc-by
sha1sum (hex)	33f082ce3f4048737a0e3d07a863487822cf3e93
schema:url	https://doi.org/10.1186/1743-422x-10-225
resource representing a document's title	Systemic varicella-zoster virus infection in two critically ill patients in an intensive care unit
has PubMed Central identifier	PMC3711847
has PubMed identifier	23829348
schema:publication	Virol J
resource representing a document's body	covid:33f082ce3f4048737a0e3d07a863487822cf3e93#body_text
is schema:about of	named entity 'VZV' named entity 'respiratory failure' named entity 'complications' named entity 'infection' named entity 'man' named entity 'complications' named entity 'patients' named entity 'infection' named entity 'BUT' named entity 'ESTABLISHED' named entity 'ZOSTER' covid:arg/33f082ce3f4048737a0e3d07a863487822cf3e93 named entity 'intensive care unit (ICU)' named entity 'pneumonia' named entity 'critically ill' named entity 'ICU' named entity 'bilaterally' named entity 'effectiveness' named entity 'acyclovir' named entity 'ICU' named entity 'critically ill' named entity 'VZV' named entity 'immunocompromised' named entity 'critically ill' named entity 'During' named entity 'systemic' named entity 'vesicles' named entity 'prophylaxis' named entity 'VZV' named entity 'pneumonia' named entity 'infection' named entity 'infection' named entity 'varicella-zoster virus' named entity 'immunocompromised patients' named entity 'immunocompromised patients' named entity 'varicella' named entity 'alanine aminotransferase' named entity 'Organ Failure' named entity 'skin lesions' named entity 'Chronic Health' named entity 'vesicles' named entity 'tumor necrosis factor-α' named entity 'acquired immunodeficiency syndrome' named entity 'prophylaxis' named entity 'DIC' named entity 'DIC' named entity 'stomachache' named entity 'necrotic lesions' named entity 'drug interactions' named entity 'Acyclovir' named entity 'high-dose' named entity 'relapse' named entity 'liver disorder' named entity 'infection' named entity 'pneumonia' named entity 'VZV' named entity 'fatal complications' named entity 'VZV' named entity 'acyclovir' named entity 'immunocompetent' named entity 'virus' named entity 'ICU' named entity 'ARDS' named entity 'infection' named entity 'intensive care units' named entity 'VZV' named entity 'chills' named entity 'pneumonia' named entity 'renal transplant' named entity 'VZV' named entity 'psoriasis vulgaris' named entity 'acyclovir' named entity 'severe respiratory failure' named entity 'intensive care' named entity 'spleen' named entity 'purpura' named entity 'transaminase' named entity 'pneumonia'

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