About: Epidemiology and Clinical Presentation of Parainfluenza Type 4 in Children: A 3-Year Comparative Study to Parainfluenza Types 1

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About: Epidemiology and Clinical Presentation of Parainfluenza Type 4 in Children: A 3-Year Comparative Study to Parainfluenza Types 1–3 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epidemiology and Clinical Presentation of Parainfluenza Type 4 in Children: A 3-Year Comparative Study to Parainfluenza Types 1–3
Creator	Dominguez, Samuel Robinson, Christine Frost, Holly
source	Medline; PMC
abstract	Background. Human parainfluenza viruses (HPIVs) are among the most common causes of respiratory tract infections in children. Little is known about the epidemiology and clinical presentation of HPIV type 4. Methods. A retrospective chart review and comparison of patients positive for HPIV types 1–4 by multiplex polymerase chain reaction between 2009 and 2012 at Children's Hospital Colorado was performed. Patients who had only direct fluorescent antibody testing performed or concurrent viral infections were excluded. Results. Of 11 533 samples, 752 (6.5%) were positive for HPIV. After exclusion criteria, 316 samples were included in the study. HPIV-4 had year-round prevalence with biennial peaks in odd-numbered years. HPIV-4 and HPIV-3 had similar clinical presentations. 50.8% and 51.5% of patients with HPIV-3–4 had hypoxia compared to 20.3% and 33.3% of patients with HPIV-1–2 (P < .01). HPIV-1 (23.6%) and HPIV-2 (24.2%) were more associated with stridor than HPIV-3 (6.6%) and HPIV-4 (0%) (P < .01). No patients with HPIV-4 had croup. Patients with HPIV-4 had similar lengths of stay and mortality as those with HPIV-1–3. Conclusions. This is the first large-scale analysis of HPIV-4 clinical and epidemiologic features. HPIV-4 was most similar to HPIV-3 in clinical presentation. HPIV-4 had year-round prevalence with peaks in the autumn of odd-numbered years. HPIV-4 is a common respiratory pathogen capable of causing significant morbidity in children.
has issue date	2013-10-16(xsd:dateTime)
bibo:doi	10.1093/infdis/jit552
bibo:pmid	24133181
has license	bronze-oa
sha1sum (hex)	33b0d67ccc6337a921154e45b32328a98a0547e3
schema:url	https://doi.org/10.1093/infdis/jit552
resource representing a document's title	Epidemiology and Clinical Presentation of Parainfluenza Type 4 in Children: A 3-Year Comparative Study to Parainfluenza Types 1–3
has PubMed Central identifier	PMC3923541
has PubMed identifier	24133181
schema:publication	The Journal of Infectious Diseases
resource representing a document's body	covid:33b0d67ccc6337a921154e45b32328a98a0547e3#body_text
is schema:about of	named entity 'COMPARATIVE STUDY' named entity 'TYPES' named entity 'CLINICAL PRESENTATION' named entity 'TYPE 4' named entity 'PARAINFLUENZA' named entity 'CHILDREN' named entity 'YEAR' named entity 'EPIDEMIOLOGY' named entity 'CRP' named entity 'virus' named entity 'influenza' named entity 'DFA' named entity 'Clinical Presentation' named entity 'Parainfluenza' named entity 'HPIV' named entity 'cytomegalovirus' named entity 'Seizure' named entity 'PCR' named entity 'pediatric patients' named entity 'infectious agent' named entity 'DFA' named entity 'electronic data capture' named entity 'oxygen' named entity 'radiographic' named entity 'HPIV-1' named entity 'epidemiology' named entity 'HPIV' named entity 'viruses' named entity 'influenza' named entity 'pharyngitis' named entity 'clinical care' named entity 'HPIV-1' named entity 'PCR' named entity 'asymptomatic carriage' named entity 'HPIV' named entity 'enterovirus' named entity 'herpes simplex virus' named entity 'Clinical presentation' named entity 'coinfections' named entity 'Wilcoxon rank-sum test' named entity 'HPIV' named entity 'HPIV-1' named entity 'Demographic information' named entity 'HPIV-1' named entity 'parainfluenza' named entity 'serologic' named entity 'influenza' named entity 'high-risk' named entity 'lower respiratory tract infections' named entity 'pediatric' named entity 'altered mental status' named entity 'immunocompromise' named entity 'virulence' named entity 'HPIV-1' named entity 'All-cause mortality' named entity 'pediatric patients' named entity 'medical conditions' named entity 'Clinical significance' named entity 'HPIV' named entity 'categorical data' named entity 'Human parainfluenza viruses' named entity 'pediatric patients' named entity 'infection' named entity 'Colorado Front Range' named entity 'neurologic conditions' named entity 'HPIV' named entity 'sampling bias' named entity 'intubation' named entity 'Erythrocyte sedimentation rate' named entity 'adenovirus' named entity 'CHCO' named entity 'croup' named entity 'lower respiratory tract infections' named entity 'otitis media' named entity 'serotypes' named entity 'retrospective chart review' named entity 'coinfections' named entity 'red eyes' named entity 'neurologic'

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