About: Development of a New Resequencing Pathogen Microarray Based Assay for Detection of Broad-Spectrum Respiratory Tract Viruses in Patients with Community-Acquired Pneumonia

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About: Development of a New Resequencing Pathogen Microarray Based Assay for Detection of Broad-Spectrum Respiratory Tract Viruses in Patients with Community-Acquired Pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development of a New Resequencing Pathogen Microarray Based Assay for Detection of Broad-Spectrum Respiratory Tract Viruses in Patients with Community-Acquired Pneumonia
Creator	Zhang, Yi Tan, Wenjie Li, Jin Wang, Miao Zhang, Chen Li, Aihua Ma, Xuejun Nie, Kai Shen, Hongwei Wang, Ji Yang, Mengjie Li, Wang Shi,
Source	Medline; PMC
abstract	A Resequencing Pathogen Microarray (RPM) is a single, highly multiplexed assay for detecting and differentiating similarly related pathogens by using closely overlapping probe sets to determine a target organism’s nucleotide sequence. In this study, a new RPM (RPM-IVDC1) that consisted of 224-bp detector tiles corresponding to 9 influenza A subtypes, 11 rhinoviruses, 28 enteroviruses and 38 other respiratory viruses was developed and optimized to provide individual and simultaneous detection sensitivities ranging from 15 to 750 genomic copies for 16 common respiratory pathogens. A total of 110 consecutive patients with community-acquired pneumonia (CAP) admitted to 5 district general hospitals in Beijing during a 1-year period were assessed using the new assay. Among the children (under age 5) and adult patients (above age 18), respiratory syncytial virus (RSV) and rhinovirus (RV) were the most common etiological agents, respectively, which is consistent with reference assays. Atypical pathogens that may cause CAP-like illness, including rubella virus, measles virus, influenza type C virus, human herpesvirus (HHV) were also detected. The results show the capability of RPM-IVDC1 for the accurate detection and identification of multiple virus types, which may be of significant use in epidemic surveillance and outbreak investigations of atypical pathogens.
has issue date	2013-09-27(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0075704
bibo:pmid	24086618
has license	cc-by
sha1sum (hex)	338d45deb88de8cc7f4cf5158c4752fb3533a0b7
schema:url	https://doi.org/10.1371/journal.pone.0075704
resource representing a document's title	Development of a New Resequencing Pathogen Microarray Based Assay for Detection of Broad-Spectrum Respiratory Tract Viruses in Patients with Community-Acquired Pneumonia
has PubMed Central identifier	PMC3785410
has PubMed identifier	24086618
schema:publication	PLoS One
resource representing a document's body	covid:338d45deb88de8cc7f4cf5158c4752fb3533a0b7#body_text
is schema:about of	named entity 'detection' named entity 'atypical' named entity 'optimized' named entity 'VIRUS TYPES' covid:arg/338d45deb88de8cc7f4cf5158c4752fb3533a0b7 named entity 'MEASLES VIRUS' named entity 'MULTIPLE' named entity 'DETECTED' named entity 'DISTRICT' named entity 'HUMAN HERPESVIRUS' named entity 'CAPABILITY' named entity 'MAY BE' named entity 'INFLUENZA A' named entity 'CONSECUTIVE' named entity 'ENTEROVIRUSES' named entity 'DETECTOR' named entity 'PROBE' named entity 'ACCURATE' named entity 'OVERLAPPING' named entity 'REFERENCE' named entity '750' named entity 'TYPE C VIRUS' named entity 'TOTAL' named entity 'RESPIRATORY VIRUSES' named entity '110' named entity 'NEW' named entity 'RESULTS' named entity 'SURVEILLANCE' named entity 'CAP' named entity 'RHINOVIRUS' named entity 'PNEUMONIA' named entity 'ACQUIRED' named entity 'PATIENTS' named entity 'STUDY' named entity 'AGE' named entity 'LIKE' named entity 'ASSESSED' named entity 'BEIJING' named entity 'USE' named entity 'SUBTYPES' named entity 'CHILDREN' named entity 'IDENTIFICATION' named entity 'PATHOGENS' named entity 'DETERMINE' named entity 'COMMON' named entity 'SIMULTANEOUS' named entity 'IS A' named entity 'RPM' named entity 'PERIOD' named entity 'TO PROVIDE' named entity 'INFLUENZA' named entity 'YEAR' named entity 'OUTBREAK' named entity 'CAUSE' named entity 'MICROARRAY' named entity 'GENOMIC' named entity 'EPIDEMIC' named entity 'INDIVIDUAL' named entity 'USING' named entity 'PATHOGEN' named entity 'CONSISTENT WITH' named entity 'INVESTIGATIONS' named entity 'RELATED' named entity 'TARGET' named entity 'ADMITTED TO' named entity 'ATYPICAL' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'RESPIRATORY PATHOGENS' named entity 'RUBELLA VIRUS'

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