About: Nosocomial COVID-19 infection: examining the risk of mortality. The COPE-Nosocomial study (COVID in Older PEople).

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About: Nosocomial COVID-19 infection: examining the risk of mortality. The COPE-Nosocomial study (COVID in Older PEople). Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nosocomial COVID-19 infection: examining the risk of mortality. The COPE-Nosocomial study (COVID in Older PEople).
Creator	Clini, Enrico Holloway, Mark Mrcp, Mbchb Collins, J Singh, Sandeep Carter, B Hospital, Alexandra Bhatti, Emma Cavenagh, Alice Davey, Charlotte Edwards, Jenny Galbraith, Norman Jones, Sheila Lunstone, Kiah Paxton, Dolcie Silver, Charlotte Simmons, Rebecca Telford, Thomas Hesford, James Verduri, A Barlow-Pay, F Bristol, North Bruce, E Carter, El, Tarik Frcp, Mbchb Jt, Collins Mbchb, Bruce Mbchb, Rickard Mbchb, Verduri Mrcp, B Mutasem, Jichi Price, Quinn, T Rickard, F Royal, Will Tj, Quinn Ystrad, Ysbyty
Source	Elsevier; Medline; PMC
abstract	INTRODUCTION: Hospital admissions for non-COVID-19 pathology have significantly reduced. It is believed that this may be due to public anxiety about acquiring COVID-19 infection in hospital and the subsequent risk of mortality. There is an urgent need for clarity regarding patients who acquire COVID-19 in hospital (nosocomial COVID-19 infection [NC]), their risk of mortality, compared to those with community acquired COVID-19 (CAC) infection. METHODS: The COPE-Nosocomial Study was an observational cohort study. The primary outcome was the time to all-cause mortality (estimated with an adjusted hazards ratio [aHR]), and secondary outcomes were Day-7 mortality and the time-to-discharge. A mixed-effects multivariable Cox’s proportional hazards model was used, adjusted for demographics and comorbidities. RESULTS: Our study included 1564 patients from 10 hospital sites throughout the UK, and one in Italy, and collected outcomes on patients admitted up to 28(th) April, 2020. 12.5% of COVID-19 infections were acquired in hospital. 425 (27.2%) patients with COVID died. The median survival time in NC patients was 14 days, which compared to 10 days in CAC patients. In the primary analysis, NC infection was associated with reduced mortality (aHR=0.71, 95%CI 0.51-0.99). Secondary outcomes found no difference in Day-7 mortality (aOR=0.79, 95%CI 0.47-1.31), but NC patients required longer time in hospital during convalescence (aHR=0.49, 95%CI 0.37-0.66). CONCLUSION: The minority of COVID-19 cases were the result of NC transmission. Whilst no COVID-19 infection comes without risk, patients with NC had a reduced risk of mortality compared to CAC infection, however, caution should be taken when interpreting this finding. In the United Kingdom, authority to conduct the study was granted by the Health Research Authority (20/HRA/1898), and in Italy by the Ethics Committee of Policlinico Hospital Modena (Reference 369/2020/OSS/AOUMO). Cardiff University was the study sponsor.
has issue date	2020-07-21(xsd:dateTime)
bibo:doi	10.1016/j.jhin.2020.07.013
bibo:pmid	32702463
has license	no-cc
sha1sum (hex)	336d8a9aa2efbb010f89043104dfd46469f1dac4
schema:url	https://doi.org/10.1016/j.jhin.2020.07.013
resource representing a document's title	Nosocomial COVID-19 infection: examining the risk of mortality. The COPE-Nosocomial study (COVID in Older PEople).
has PubMed Central identifier	PMC7372282
has PubMed identifier	32702463
schema:publication	J Hosp Infect
resource representing a document's body	covid:336d8a9aa2efbb010f89043104dfd46469f1dac4#body_text
is schema:about of	named entity 'anxiety' named entity 'infection' named entity 'COVID-19' named entity 'ACQUIRING' covid:arg/336d8a9aa2efbb010f89043104dfd46469f1dac4 named entity 'mortality' named entity 'biomarkers' named entity 'psychological impact' named entity 'Hospital' named entity 'infection' named entity 'COVID' named entity 'infection' named entity 'COVID' named entity 'COVID' named entity 'COVID-19 infection' named entity 'Older PEople' named entity 'COVID-19 infection' named entity 'COVID' named entity 'Nosocomial' named entity 'COVID-19' named entity 'ventilator' named entity 'COVID' named entity 'CRP' named entity 'medical attention' named entity 'infection' named entity 'infection' named entity 'cohort study' named entity 'anxiety' named entity 'lockdown' named entity 'mortality rates' named entity 'indwelling catheter' named entity 'Incubation' named entity 'COVID' named entity 'medical attention' named entity 'England' named entity 'diabetes' named entity 'epidemic' named entity 'cohort studies' named entity 'COVID' named entity 'infection control' named entity 'Data quality' named entity 'intensive care units' named entity 'observational study' named entity 'COVID'

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