About: Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination

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About: Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination
Creator	Doganay Duru, Adil Han, Xiao Kadri, Nadir Madhurantakam, Chaithanya Sandalova, Tatyana Peqini, Kaliroi Achourid, Adnane Allerbringid, Eva Chaddertonid, Jesseka Nygrenid, Pellegrinoid, Sara Sunid, Turnerid, Stephen Uchtenhagenid, Hannes
Source	PMC
abstract	Viral escape from CD8(+) cytotoxic T lymphocyte responses correlates with disease progression and represents a significant challenge for vaccination. Here, we demonstrate that CD8(+) T cell recognition of the naturally occurring MHC-I-restricted LCMV-associated immune escape variant Y4F is restored following vaccination with a proline-altered peptide ligand (APL). The APL increases MHC/peptide (pMHC) complex stability, rigidifies the peptide and facilitates T cell receptor (TCR) recognition through reduced entropy costs. Structural analyses of pMHC complexes before and after TCR binding, combined with biophysical analyses, revealed that although the TCR binds similarly to all complexes, the p3P modification alters the conformations of a very limited amount of specific MHC and peptide residues, facilitating efficient TCR recognition. This approach can be easily introduced in peptides restricted to other MHC alleles, and can be combined with currently available and future vaccination protocols in order to prevent viral immune escape.
has issue date	2020-05-04(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1008244
bibo:pmid	32365082
has license	cc-by
sha1sum (hex)	336a3bfa467c4c7b1e75852eae04ba60d1efaaf5
schema:url	https://doi.org/10.1371/journal.ppat.1008244
resource representing a document's title	Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination
has PubMed Central identifier	PMC7224568
has PubMed identifier	32365082
schema:publication	PLoS Pathog
resource representing a document's body	covid:336a3bfa467c4c7b1e75852eae04ba60d1efaaf5#body_text
is schema:about of	named entity 'TCR' named entity 'Sun' named entity 'entropy' named entity 'vaccination' named entity 'alters' named entity 'stability' named entity 'introduced' named entity 'facilitates' named entity 'peptide' named entity 'immune' named entity 'MHC' named entity 'peptide' named entity 'vaccination' named entity 'alleles' named entity 'TCR' named entity 'CD8 +' named entity 'peptides' named entity 'peptide' named entity 'Chadderton' named entity 'naturally occurring' named entity 'Viral' named entity 'APL' named entity 'peptide' named entity 'proline' named entity 'conformations' named entity 'cytotoxic T lymphocyte' named entity 'ligand' named entity 'doi' named entity 'vaccination' named entity 'proline' named entity 'antiviral' named entity 'TCR' named entity 'heavy chain' named entity 'E163' named entity 'vaccination' named entity 'APLs' named entity 'CD107a' named entity 'cross-reactive' named entity 'MHC' named entity 'red blood cell' named entity 'p3P' named entity 'peptide' named entity 'entropic' named entity 'heavy chain' named entity 'avidity' named entity 'electron density' named entity 'cytokine' named entity 'clone' named entity 'surface plasmon resonance' named entity 'MHC' named entity 'APLs' named entity 'CTL' named entity 'peptides' named entity 'antibodies' named entity 'proline' named entity 'immunodominant' named entity 'peptide' named entity 'endogenous' named entity 'Refolding' named entity 'mice' named entity 'plasmid' named entity 'PHASER' named entity 'epitopes' named entity 'down-regulation' named entity 'transgenic mice' named entity 'crystal structures' named entity 'heterogeneity' named entity 'TCR'

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