About: Putative progressive and abortive feline leukemia virus infection outcomes in captive jaguarundis (Puma yagouaroundi)

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About: Putative progressive and abortive feline leukemia virus infection outcomes in captive jaguarundis (Puma yagouaroundi) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Putative progressive and abortive feline leukemia virus infection outcomes in captive jaguarundis (Puma yagouaroundi)
Creator	Reinacher, Manfred Hofmann-Lehmann, Regina Filoni, Claudia Katrin Helfer-Hungerbuehler, A Marques, Mara Luiz Catão-Dias, José Torres, Luciana
Source	Medline; PMC
abstract	BACKGROUND: Feline leukemia virus (FeLV) is an exogenous gammaretrovirus of domestic cats (Felis catus) and some wild felids. The outcomes of FeLV infection in domestic cats vary according to host susceptibility, virus strain, and infectious challenge dose. Jaguarundis (Puma yagouaroundi) are small wild felids from South and Central America. We previously reported on FeLV infections in jaguarundis. We hypothesized here that the outcomes of FeLV infection in P. yagouaroundi mimic those observed in domestic cats. The aim of this study was to investigate the population of jaguarundis at Fundação Parque Zoológico de São Paulo for natural FeLV infection and resulting outcomes. METHODS: We investigated the jaguarundis using serological and molecular methods and monitored them for FeLV-related diseases for 5 years. We retrieved relevant biological and clinical information for the entire population of 23 jaguarundis held at zoo. Post-mortem findings from necropsies were recorded and histopathological and immunohistopathological analyses were performed. Sequencing and phylogenetic analyses were performed for FeLV-positive samples. For sample prevalence, 95% confidence intervals (CI) were calculated. Fisher’s exact test was used to compare frequencies between infected and uninfected animals. P-values <0.05 were considered significant. RESULTS: In total, we detected evidence of FeLV exposure in four out of 23 animals (17%; 95% CI 5–39%). No endogenous FeLV (enFeLV) sequences were detected. An intestinal B-cell lymphoma in one jaguarundi was not associated with FeLV. Two jaguarundis presented FeLV test results consistent with an abortive FeLV infection with seroconversion, and two other jaguarundis had results consistent with a progressive infection and potentially FeLV-associated clinical disorders and post-mortem changes. Phylogenetic analysis of env revealed the presence of FeLV-A, a common origin of the virus in both animals (100% identity) and the closest similarity to FeLV-FAIDS and FeLV-3281 (98.4% identity), originally isolated from cats in the USA. CONCLUSIONS: We found evidence of progressive and abortive FeLV infection outcomes in jaguarundis, and domestic cats were probably the source of infection in these jaguarundis.
has issue date	2017-11-17(xsd:dateTime)
bibo:doi	10.1186/s12985-017-0889-z
bibo:pmid	29149857
has license	cc-by
sha1sum (hex)	3341998ccda48a6464d056736f52a967b45df144
schema:url	https://doi.org/10.1186/s12985-017-0889-z
resource representing a document's title	Putative progressive and abortive feline leukemia virus infection outcomes in captive jaguarundis (Puma yagouaroundi)
has PubMed Central identifier	PMC5693524
has PubMed identifier	29149857
schema:publication	Virol J
resource representing a document's body	covid:3341998ccda48a6464d056736f52a967b45df144#body_text
is schema:about of	named entity 'Post-mortem' named entity 'samples' named entity 'vary' named entity 'FeLV' named entity 'infection' named entity 'USA' named entity 'VIRUS' named entity 'RELEVANT' named entity 'RELATED' named entity 'HERE' named entity 'A COMMON' named entity 'AIM' named entity 'PROBABLY' named entity 'ASSOCIATED WITH' named entity '28100' named entity 'DISEASES' named entity 'PERFORMED' named entity 'EXPOSURE' named entity 'SAMPLES' named entity 'ENV' named entity 'HOST' named entity 'SEROLOGICAL' named entity 'USA' named entity 'EXACT TEST' named entity 'USED' named entity 'PRESENCE OF' named entity 'STUDY' named entity 'REVEALED' named entity 'VALUES' named entity 'SEROCONVERSION' named entity 'YEARS' named entity 'COMMON ORIGIN' named entity 'STRAIN' named entity 'OUTCOMES' named entity 'MONITORED' named entity 'CATS' named entity 'ASSOCIATED' named entity 'HISTOPATHOLOGICAL' named entity 'FELIDS' named entity 'CALCULATED' named entity 'INFECTIONS' named entity 'SIGNIFICANT' named entity 'FELINE LEUKEMIA VIRUS INFECTION' named entity 'CONCLUSIONS' named entity 'SIMILARITY' named entity 'GAMMARETROVIRUS' named entity 'USING' named entity 'PRESENTED' named entity 'CHALLENGE DOSE' named entity 'FISHER' named entity 'THESE' named entity 'SAMPLE' named entity 'ISOLATED' named entity 'SEQUENCES' named entity 'DOMESTIC' named entity 'BACKGROUND' named entity 'CONSISTENT WITH' named entity 'CONSIDERED' named entity 'PREVALENCE' named entity 'CENTRAL AMERICA' named entity 'SUSCEPTIBILITY' named entity 'MOLECULAR' named entity 'CLINICAL' named entity 'B-CELL LYMPHOMA' named entity 'FELINE LEUKEMIA VIRUS' named entity 'TO COMPARE' named entity 'UNINFECTED' named entity 'INTESTINAL' named entity 'OUTCOMES' named entity 'ACCORDING' named entity 'FOUND' named entity 'INFECTED' named entity 'FREQUENCIES' named entity 'EVIDENCE OF' named entity 'SEQUENCING'

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