About: Potential of SARS-CoV-2 to Cause CNS Infection: Biologic Fundamental and Clinical Experience

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About: Potential of SARS-CoV-2 to Cause CNS Infection: Biologic Fundamental and Clinical Experience Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Potential of SARS-CoV-2 to Cause CNS Infection: Biologic Fundamental and Clinical Experience
Creator	Matias-Guiu, Jorge Chen, Yaxing Huang, Jianhan Pytel, Vanesa Serrano-Castro, Pedro Tang, Xin Tong, Aiping Zheng, Meijun Zhou, Liangxue
Source	Medline; PMC
abstract	SARS-CoV-2 is a novel coronavirus leading to serious respiratory disease and is spreading around the world at a raging speed. Recently there is emerging speculations that the central nervous system (CNS) may be involved during SARS-CoV-2 infection, contributing to the respiratory failure. However, the existence of viral replication in CNS has not been confirmed due to the lack of evidence from autopsy specimens. Considering the tropism of SARS-CoV-2, ACE2, is prevailing in CNS, and the neuro-invasive property of human coronavirus was widely reported, there is a need to identified the possible complications during COVID-19 for CNS. In this review, we conduct a detailed summary for the potential of SARS-CoV-2 to infect central nervous system from latest biological fundamental of SARS-CoV-2 to the clinical experience of other human coronaviruses. To confirm the neuro-invasive property of SARS-CoV-2 and the subsequent influence on patients will require further exploration by both virologist and neurologist.
has issue date	2020-06-18(xsd:dateTime)
bibo:doi	10.3389/fneur.2020.00659
bibo:pmid	32625165
has license	cc-by
sha1sum (hex)	33359bd7f92f9663983e38e693f5f3826842a640
schema:url	https://doi.org/10.3389/fneur.2020.00659
resource representing a document's title	Potential of SARS-CoV-2 to Cause CNS Infection: Biologic Fundamental and Clinical Experience
has PubMed Central identifier	PMC7314941
has PubMed identifier	32625165
schema:publication	Front Neurol
resource representing a document's body	covid:33359bd7f92f9663983e38e693f5f3826842a640#body_text
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