About: The importance of cellular-scale viral dynamics in bat reservoirs for emerging zoonotic disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The importance of cellular-scale viral dynamics in bat reservoirs for emerging zoonotic disease
Creator	Drosten, Christian Grenfell, Bryan Wang, Lin-Fa Chandran, Kartik Boots, Mike Ng, Melinda Müller, Marcel Brook, Cara Dobson, Andrew Graham, Andrea Van Leeuwen, Anieke
Source	BioRxiv; MedRxiv
abstract	Bats host virulent zoonotic viruses without experiencing disease. A mechanistic understanding of the impact of bats’ virus hosting capacities, including uniquely constitutive immune pathways, on cellular-scale viral dynamics is needed to elucidate zoonotic emergence. We carried out virus infectivity assays on bat cell lines expressing induced and constitutive immune phenotypes, then developed a theoretical model of our in vitro system, which we fit to empirical data. Best fit models recapitulated expected immune phenotypes for representative cell lines, supporting robust antiviral defenses in bat cells that correlated with higher estimates for within-host viral propagation rates. In general, heightened immune responses limit pathogen-induced cellular morbidity to promote the establishment of rapidly-propagating persistent infections within-host. Rapidly-replicating viruses that have evolved with bat immune systems will likely cause enhanced virulence following emergence into secondary hosts with immune systems that diverge from those unique to bats.
has issue date	2019-12-31(xsd:dateTime)
bibo:doi	10.1101/696195
has license	biorxiv
sha1sum (hex)	32c2e402c3c88c3024a4dec3d78ba67c24f89ca6
schema:url	https://doi.org/10.1101/696195
resource representing a document's title	The importance of cellular-scale viral dynamics in bat reservoirs for emerging zoonotic disease
schema:publication	bioRxiv
resource representing a document's body	covid:32c2e402c3c88c3024a4dec3d78ba67c24f89ca6#body_text
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