About: Comparison of Humoral Immune Responses to Epstein-Barr Virus and Kaposi’s Sarcoma–Associated Herpesvirus Using a Viral Proteome Microarray

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About: Comparison of Humoral Immune Responses to Epstein-Barr Virus and Kaposi’s Sarcoma–Associated Herpesvirus Using a Viral Proteome Microarray Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparison of Humoral Immune Responses to Epstein-Barr Virus and Kaposi’s Sarcoma–Associated Herpesvirus Using a Viral Proteome Microarray
Creator	Qian, Jiang Zhu, Heng Wang, Leyao Wan, Jun Chiou, Chuang-Jiun Liao, Gangling Martinez-Maza, Otoniel Pai, Shweta Woodard, Crystal Zheng, Dasheng Zhu, Jian Cho, Yong Hayward, S Ambinder, Richard Hayward, Gary
Source	PMC
abstract	Background. Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, and Kaposi’s sarcoma–associated herpesvirus (KSHV) has a restricted seroprevalence. Both viruses are associated with malignancies that have an increased frequency in individuals who are coinfected with human immunodeficiency virus type 1 (HIV-1). Methods. To obtain an overview of humoral immune responses to these viruses, we generated a protein array that displayed 174 EBV and KSHV polypeptides purified from yeast. Antibody responses to EBV and KSHV were examined in plasma from healthy volunteers and patients with B cell lymphoma or with AIDS-related Kaposi’s sarcoma or lymphoma. Results. In addition to the commonly studied antigens, IgG responses were frequently detected to the tegument proteins KSHV ORF38 and EBV BBRF and BGLF2 and BNRF1 and to the EBV early lytic proteins BRRF1 and BORF2. The EBV vIL-10 protein was particularly well recognized by plasma IgA. The most intense IgG responses to EBV antigens occurred in HIV-1–positive patients. No clear correlation was observed between viral DNA load in plasma and antibody profile. Conclusions. The protein array provided a sensitive platform for global screening; identified new, frequently recognized viral antigens; and revealed a broader humoral response to EBV compared with KSHV in the same patients.
has issue date	2011-10-11(xsd:dateTime)
bibo:doi	10.1093/infdis/jir645
bibo:pmid	21990424
has license	bronze-oa
sha1sum (hex)	32bedc74792d5bab6b1dd4f389919fabb612c8d1
schema:url	https://doi.org/10.1093/infdis/jir645
resource representing a document's title	Comparison of Humoral Immune Responses to Epstein-Barr Virus and Kaposi’s Sarcoma–Associated Herpesvirus Using a Viral Proteome Microarray
has PubMed Central identifier	PMC3203236
has PubMed identifier	21990424
schema:publication	The Journal of Infectious Diseases
resource representing a document's body	covid:32bedc74792d5bab6b1dd4f389919fabb612c8d1#body_text
is schema:about of	named entity 'individuals' named entity 'human immunodeficiency virus' named entity 'Immune' named entity 'Herpesvirus' named entity 'IS A' named entity 'MALIGNANCIES' named entity 'RESTRICTED' named entity 'Sarcoma' named entity 'Virus' named entity 'malignancies' named entity 'Epstein-Barr virus' named entity 'Microarray' named entity 'Herpesvirus' named entity 'Humoral Immune Responses' named entity 'G-protein coupled receptor' named entity 'serum' named entity 'KSHV' named entity 'KSHV' named entity 'lymphoma' named entity 'Cy3' named entity 'epitopes' named entity 'EBNA1' named entity 'microarrays' named entity 'EBV' named entity 'antibody' named entity 'Bio-Rad' named entity 'IgA' named entity 'KSHV' named entity 'amino acids' named entity 'KSHV' named entity 'IgG' named entity 'IgG' named entity 'KSHV' named entity 'viral proteins' named entity 'humoral response' named entity 'antigens' named entity 'EBV' named entity 'virus' named entity 'EBV' named entity 'men who have sex with men' named entity 'exon' named entity 'amino acids' named entity 'vector' named entity 'EBV' named entity 'N-terminus' named entity 'correlation' named entity 'KSHV' named entity 'plasma' named entity 'correlation' named entity 'N-terminus' named entity 'repeated sequences' named entity 'lymphoma' named entity 'endothelial cells' named entity 'epithelial cells' named entity 'KSHV' named entity 'HIV-1' named entity 'IgG' named entity 'DNA copy number' named entity 'polypeptides' named entity 'herpesvirus' named entity 'EBV' named entity 'BSA' named entity 'viral capsid' named entity 'plasma' named entity 'AIDS-related lymphoma' named entity 'KSHV' named entity 'saliva'

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